미만성 경화 변종 갑상선 유두암의 임상적 고찰

김영범; 박훈; 최주열; 박성호; 이국행; 이병철; 이명철; 최익준

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자료유형: 학술저널

저자정보: 김영범 박훈 최주열 박성호 이국행 이병철 이명철 최익준

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제56권 제11호

발행연도: 2013.1

수록면: 711 - 716 (6page)

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Background and Objectives Diffuse sclerosing variant (DSV) is a rare variant of papillary thyroid carcinoma (PTC) and has been adopted as a histologic variant. Due to the limited number of cases and the heterogeneity of the tumor’s clinical behavior, there is no consensus for DSV’s optimal treatment and post-operative follow-up. The purpose of this study is to evaluate the clinical manifestation, recurrence and prognosis of 10 patients with DSV. Subjects and Method We retrospectively reviewed ten consecutive patients in whom DSV was first observed between 2000 and 2012. All patients are presently under active follow-up at Korea Cancer Center Hospital. Patients underwent a total thyroidectomy with central compartment and laterocervical lymph node dissection only when this involvement was documented by pre-surgery ultrasound examination with fine needle aspiration biopsy. Results The mean observation interval was 41.6 months. The ratio of male to female was 1 : 9, and the age of incidence was 34.2±11.4. The average size of mass was measured 2.9±1.9 cm. Upon the diagnosis, eight cases had central and lateral neck lymph nodal metastasis, which was confirmed during the operation. There was no distant metastasis, but one case was confirmed with lung metastasis during the follow-up period. There was no mortality during the follow-up periods in all ten cases. Conclusion DSV of PTC has high risk characteristics of large tumor size, extrathyroidal extension, and multiple lymph nodes metastasis. We may expect comparable outcome with classical PTC by proper surgical treatment and postoperative radioactiveiodine ablation.

#Diffuse sclerosing variant #Papillary thyroid carcinoma.

참고문헌 (16)

참고문헌 신청

Albareda M / 1998 / Clinical forms of presentation and evolution of diffuse sclerosing variant of papillary carcinoma and insular variant of follicular carcinoma of the thyr

Carcangiu ML / 1989 / Diffuse sclerosing variant of papillary thyroid carcinoma. Clinicopathologic study of 15 cases / Am J Surg Pathol 13 (12) : 1041 ~ 1049

Chow SM / 2003 / Diffuse sclerosing variant of papillary thyroid carcinoma--clinical features and outcome / Eur J Surg Oncol 29 (5) : 446 ~ 449

Falvo L / 2006 / Prognostic importance of sclerosing variant in papillary thyroid carcinoma / Am Surg 72 (5) : 438 ~ 444

Fujimoto Y / 1990 / Diffuse sclerosing variant of papillary carcinoma of the thyroid. Clinical importance, surgical treatment, and follow-up study / Cancer 66 : 2306 ~ 2312