타액선에 발생한 선양낭성암의 치료 후 재발

권민수; 노종렬; 최승호; 김상윤; 남순열

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자료유형: 학술저널

저자정보: 권민수 노종렬 최승호 김상윤 남순열

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제2호

발행연도: 2009.1

수록면: 154 - 160 (7page)

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Background and Objectives：Adenoid cystic carcinoma of salivary glands has distinct characteristics of indolent but persistent growth, late onset of metastasis and eventual death of patients. We performed this study to find parameters affecting the recurrence and survival of patients with adenoid cystic carcinoma in salivary glands. Subjects and Method：A retrospective study was done on 55 patients who underwent surgery between 1990 and 2006. We analyzed the effect of patient’s factors, characteristics of tumor and treatment modalities to local recurrence, distant metastasis and survival. Results：There were 20 males and 35 females, with the median age of 50.2 years. The mean follow-up duration after treatment was 70.9 months. Patients who received surgery alone were 12 (22%), with radiation therapy were 34 (62%) and with concurrent chemoradiation therapy were 9 (16%). There were 7 patients who had local recurrence alone, 8 who had distant metastasis alone and 3 who had local recurrence with distant metastasis. There was no correlation between the above parameters and local recurrence. Distant metastasis was influenced by old age (p= 0.018), lymph node involvement (p=0.005) and treatment with concurrent chemoradiation therapy (p<0.001). Eight patients died during the follow up period. Five-year overall survival rate was 88.2% and the disease-free survival was 72.9%. The multivariate analysis found that only lymph node involvement was associated with survival (p=0.043). Conclusion：Lymph node involvement was predictive of poor prognosis in salivary adenoid cystic carcinoma. Therefore, it is necessary to establish highly sensitive diagnostic tools with which surgeons can find lymph node involvement.

#선양낭성암·타액선·임파선 침습 #Adenoid cystic carcinoma·Salivary gland·Lymph node involvement

참고문헌 (26)

참고문헌 신청

World Health Organization Classification of Tumors / 2005 / Pathology and genetics / Head and Neck Tumors

Garden AS / 1995 / The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation / Int J Radiat Oncol Biol Phys 32(3):619~626

Mendenhall WM / 2004 / Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck / Head Neck 26(2):154~162

Chen AM / 2006 / Adenoid cystic carcinoma of the head and neck treated by surgery with or without postoperative radiation therapy: Prognostic features of recurrence / Int J Radiat Oncol Biol Phys 166:152~159

Zhang J / 2005 / Expression of nuclear factor kappa B, inducible nitric oxide synthase, and vascular endothelial growth factor in adenoid cystic carcinoma of salivary glands: Correlations with the angiogenesis and clinical outcome / Clin Cancer Res 11(20):7334~7343

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