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Background and Objectives: (MALT), which has evolved to protect vulnerable mucosal surfaces. Helicobacter pylori, implicated as an etiological factor in duodenal ulcer and gastritis, induces the apearance of lymphoid agregates in the stomach. Therefore, we investigate the posibility that tonsils can be extragastric reservoir and target tissue for H. pylori. Subjects and Method:Campylobacter-Like Organism (CLO) test and imunohistochemical (IHC) analysis for H. pylorigroup (62 patients) and controled group (36 patients) were enrolled in this study. Tisue samples were collected from excised palatine tonsils. Two millimeter diameter tissue piece that had ben obtained from palatine tonsil specimens were placed in the CLO test kit. Remnant tonsils were sent to the Department of Pathology for IHC analysis. Results:Using the CLO test, H. pylori was detected in 60 (61.2%) of the 98 patients, 39 (62.9%) of 62 in chronic tonsillitis group and 21 (58.3%) of 36 in control group. Using the IHC analysis, it was detected in 54 (55.1%) of the 98 patients, 35 (56.5%) of 62 in chronic tonsillitis group and 19 (52.8%) of 36 in control group. There are no significant diferences between chronic tonsillitis group and control group with regard to both CLO & IHC analysis. Conclusion:This result sugests that palatine tonsil represents an extragastric reservoir for H. pylori infection, but not a target tisue. (Korean J Otorhinolaryngol-Head Neck Surg 2007 ;50 :616-21)

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