두경부암 환자에서 루골용액을 이용한 식도 내시경 선별검사

하남욱; 이강대; 이형신; 홍종철; 이환호; 박선자

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자료유형: 학술저널

저자정보: 하남욱 이강대 이형신 홍종철 이환호 박선자

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제10호

발행연도: 2006.1

수록면: 1,008 - 1,013 (6page)

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Background and Objectives：Second primary esophageal cancer has been reported to comprise 6-9% of head and neckcancer cases, which are frequently detected in the advanced stage. Thus, detecting esophageal cancer in the early stage is importantin the prognosis of head and neck cancer. However, it is difficult to detect early lesions using the conventional endoscopy.In the current study, the feasibility of endoscopic screening using Lugols solution was assessing for detecting early esophagealcancer in patients of head and neck cancer. Subjects and Method：Sixty-two patients (Group I-synchronous cancer studygroup) diagnosed with head and neck cancer between November, 2003 and November, 2004 were prospectively studied. Fortysixpatients (Group II-metachronous cancer study group) under the follow-up care with head and neck cancer during the sameperiod were also evaluated. The esophagus was initially observed under direct endoscopic view and then Lugol dye was sprayedat the esophagus. Any unstained area was biopsied. Results：Of 34 patients (54.8%) with unstained lesions in Group I, 10(16.1%) showed dysplasia and 4 (6.4%) had cancer. Of 21 patients (45.6%) with unstained lesions in Group II, 2 (4.3%)showed dysplasia and 5 (10.8%) had cancer. Among 9 (8.3%) second primary esophageal cancer, 6 were detected with superficialesophageal cancer while the other 3 were found to be in the advanced stage of cancer. This superficial cancer revealed nonspecificmucosal findings in the direct endoscopic view and was difficult to be visualized as a pathologic lesion; however, itrevealed unstained areas when Lugol’s solution was sprayed, thus could be diagnosed as cancer through biopsy of the area.Conclusion：Endoscopy of esophagus with Lugol’s solution could be highly effective as a screening method to detect secondprimary esophageal cancer in patients with head and neck cancer. (Korean J Otolaryngol 2006;49:1008-13)

#두경부암·이차 원발암·루골용액. #Head and neck cancer·Second primary·Lugol's solution.

참고문헌 (20)

참고문헌 신청

/ / Clinical implications of multicentric origin : 963 ~ 8

/ / Multiple primary cancer inpatients with cancer of the head and neck Second cancer of the headand neck : 467 ~ 76

/ / Smoking and drinking in relation to cancers of the oral cavity and esophagus in Northern Italy serrai (d) : 6502 ~ 7

/ 1985 / Subsequent upper aerodigestivemalignancies following treatment of esophageal cancer 55 : 1882 ~ 5

/ 1988 / Lugol-combinedendoscopic detection of minute malignant lesions of the thoracicesophagus 208 : 179 ~ 83

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