제2형 당뇨환자에서 발생한 돌발성 난청의 치료제로서 Lipo-Prostalandin E₁의 효능분석

안중호; 김태용; 김영진; 한명월; 윤태현; 이광선; 정종우

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자료유형: 학술저널

저자정보: 안중호 김태용 김영진 한명월 윤태현 이광선 정종우

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제10호

발행연도: 2006.1

수록면: 973 - 977 (5page)

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Background and Objectives：Diabetes mellitus (DM) is a risk factor for sudden sensorineural hearing loss (SSNHL), possiblydue to microvascular damage as well as increased blood viscosity and embolic and thrombotic episodes. To perform a prospective,randomized clinical trial to evaluate the therapeutic effect of lipo-prostaglandin E1 (lipo-PGE1) on SSNHL in Korean patientswith type 2 diabetes. Materials and Method：The study group consisted of 270 patients (130 males, 140 females) consecutivelydiagnosed with SSNHL. Patients were classified as diabetic or nondiabetic by the new American Diabetes Association criteria. Withthe approval of the institute ethics committee, patients were randomly assigned to treatment with a continuous infusion of 10 Llipo-PGE1 (lipo-PGE1 group) or saline (placebo group). In addition, all patients studied were treated with 48 mg methylprednisolonefor 5 days. Results：The overall recovery rates after treatment were 51.5% in diabetic and 64.2% in nondiabetic patients. Indiabetic patients, there was a significantly higher rate of hearing improvement in the lipo-PGE1 group (64.7%) than in the placebogroup (37.5%), whereas, in nondiabetic patients, there was no significant difference in the rate of hearing improvement betweenthe lipo-PGE1 group (70.3%) and the placebo group (58.3%). Conclusion：Lipo-PGE1 may have beneficial effects in the treatmentof SSNHL in Korean patients with type 2 diabetes. (Korean J Otolaryngol 2006;49:973-7)

#당뇨병·돌발성 난청·Lipo-PGE1. #Diabetes mellitus·Sudden hearing loss·Lipo-prostaglandin E1.

참고문헌 (18)

참고문헌 신청

/ / Innerear damage secondary to diabetes mellitus Changes in agingSHR/N-cp rats : 397 ~ 400

/ 1967 / Inner ear pathology in experimental diabetes 77 : 68 ~ 75

/ 1967 / Prostaglandins:Their disappearance from andrelease into the circulation 216 : 868 ~ 73

/ 1970 / Diery prevention of hearing loss 70 : 242 ~ 7

/ 1975 / The treatment of idiopathic sudden sensorineural hearingloss 8 : 467 ~ 73

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