타액선 선양낭성암종과 다형선종에서 종양 표지자 발현의 의의

최성준; 조성일; 도남용; 이준한; 최지윤; 임성철

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자료유형: 학술저널

저자정보: 최성준 조성일 도남용 이준한 최지윤 임성철

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제4호

발행연도: 2008.1

수록면: 336 - 342 (7page)

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초록· 키워드

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Salivary gland tumors are characterized by extreme histological diversity. Even within a single tumor, various histological patterns are observed. The same histological patterns are shared among various tumor types, regardless of the biological behavior, making diagnosis difficult. Although a great number of immunohistochemical studies of major salivary gland tumors have been published, their clinical and diagnostic implications are not fully apparent. We have performed basic immunohistochemical stains of pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) to determine the diagnostic value of c-kit, Ki-67, glial fibrillary acidic protein (GFAP) and p53. Materials and Method：Paraffin-embedded tissue specimens from 48 cases, who were diagnosed as PA (n=31) and ACC (n=17) from 1993 to 2002, were immunohistochemically stained for c-kit, Ki-67, GFAP and p53. Results：In the immunohistochemical stains of c-kit, Ki-67 and p53, there were no difference between PA and ACC. However, in the immunohistochemical stain of GFAP, there were difference in PA and ACC. GFAP was expressed in 74% of the PA and was not expressed in all cases of ACC. Conclusion：These data suggest that GFAP immunoreactivity could be helped in the occasional differential diagnostic dilemma of pleomorphic adenoma versus adenoid cystic carcinoma in salivary gland. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:336-42)

#Glial fibrillary acidic protein·Pleomorphic adenoma·Adenoid cystic carcinoma.

참고문헌 (20)

참고문헌 신청

Banks L / 1986 / Isolation of human-p53-specific monoclonal antibodies and their use in the studies of human p53 expression / Eur J Biochem 159 (3) : 529 ~ 534

Bock E / 1977 / Demonstration of a protein immunochemically related to glial fibrillary acidic protein in human fibroblasts in culture / FEBS Lett 83 (2) : 212 ~ 216

Edwards PC / 2003 / C-kit expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma and monomorphic adenoma / Oral SurgOral

Entz-Werle N / 2005 / Prognostic significance of allelic imbalance at the c-kit gene locus and c-kit overexpression by immunohistochemistry in pediatric osteosarcomas / J Cli

Grizzle WE / 1998 / Immunohistochemical evaluation of biomarkers in prostatic and colorectal neoplasia, in : Tumor marker protocols. Methods in molecular biology. Volume 14 / The Humana

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