갑상선 유두상암종에서 Glucose transporter-1의 발현과 Positron Emission Tomography에서 18F-Fluorodeoxyglucose 섭취와의 관계

이자현; 배소영; 박은희; 구혜수; 배문선; 정성민; 김한수

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자료유형: 학술저널

저자정보: 이자현 배소영 박은희 구혜수 배문선 정성민 김한수

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제4호

발행연도: 2008.1

수록면: 343 - 349 (7page)

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18F-FDG Positron emission tomography (18F-FDG PET) is a noninvasive diagnostic tool for many kinds of human cancer, where glucose transporter-1 (Glut-1) acts as a main transporter in the uptake of 18F-FDG in cancer cells. The object of this study is to assess the expression of Glut-1 in human papillary carcinoma and the relationship between the expression and the uptake of 18F-FDG PET. Subjects and Method：We evaluated 30 patients diagnosed as papillary carcinoma. Tumor sizes were measured and Glut-1 expression rate (ER), expression intensity (EI) and total expression score (ES) were analyzed. 18F-FDG PET was performed in 19 patients and standardized uptake value (SUV) was measured in each case. The correlations between ER and SUV, ES and SUV, tumor sizes and SUV, ER and tumor sizes were analyzed statistically. Results：96.7% (29/30) of tumors were Glut-1 positive, the mean ER was 67.42±22.89% and the mean ES 131.8±71. Tumor cells showed higher expression of Glut-1 than normal thyroid tissue. 18F-FDG uptake was positive in 81% (17/21) of solitary thyroid papillary carcinoma and negative in 19% (4/21). The average SUV of the PET positive group was 6.75±4.8, ER 71.25 ±20.6% and ES 134.68±51.4. The average size of PET positive tumors was 3.37±2.94 cm2 and that of negative tumors was 0.43±0.45 cm2. Both ER and ES of Glut-1 were correlated with SUV significantly. The size and SUV were also correlated significantly. But the size and ER were not correlated significantly. Conclusion：Thyroid papillary carcinoma has high ER of Glut-1 and there is a positive correlation between Glut-1 expression and the uptake of 18F-FDG PET. The size of tumor can also affect the 18F-FDG uptake. But there is no correlation between the size and Glut-1 expression and further studies are needed to find the mechanisms and to decide the cut-off value. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:343-9)

18F-FDG Positron emission tomography (18F-FDG PET) is a noninvasive diagnostic tool for many kinds of human cancer, where glucose transporter-1 (Glut-1) acts as a main transporter in the uptake of 18F-FDG in cancer cells. The object of this study is to assess the expression of Glut-1 in human papillary carcinoma and the relationship between the expression and the uptake of 18F-FDG PET. Subjects and Method：We evaluated 30 patients diagnosed as papillary carcinoma. Tumor sizes were measured and Glut-1 expression rate (ER), expression intensity (EI) and total expression score (ES) were analyzed. 18F-FDG PET was performed in 19 patients and standardized uptake value (SUV) was measured in each case. The correlations between ER and SUV, ES and SUV, tumor sizes and SUV, ER and tumor sizes were analyzed statistically. Results：96.7% (29/30) of tumors were Glut-1 positive, the mean ER was 67.42±22.89% and the mean ES 131.8±71. Tumor cells showed higher expression of Glut-1 than normal thyroid tissue. 18F-FDG uptake was positive in 81% (17/21) of solitary thyroid papillary carcinoma and negative in 19% (4/21). The average SUV of the PET positive group was 6.75±4.8, ER 71.25 ±20.6% and ES 134.68±51.4. The average size of PET positive tumors was 3.37±2.94 cm2 and that of negative tumors was 0.43±0.45 cm2. Both ER and ES of Glut-1 were correlated with SUV significantly. The size and SUV were also correlated significantly. But the size and ER were not correlated significantly. Conclusion：Thyroid papillary carcinoma has high ER of Glut-1 and there is a positive correlation between Glut-1 expression and the uptake of 18F-FDG PET. The size of tumor can also affect the 18F-FDG uptake. But there is no correlation between the size and Glut-1 expression and further studies are needed to find the mechanisms and to decide the cut-off value. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:343-9)

#Papillary carcinoma· Glucose transporter-1· PET.

참고문헌 (21)

참고문헌 신청

Barrington, Sally F / 2006 / Atlas of clinical positron emission tomography / Hodder Arnold : 25 ~ 120

Brown RS / 1999 / Flint A, Wahl RL. Glucose transporters and FDG uptake in untreated primary human non-small cell lung cancer / J Nucl Med 40 (4) : 556 ~ 565

Chung JK / 1999 / Mechanisms related to 18F-fluorodeoxyglucose uptake of human colon cancers transplanted in nude mice / J Nucl Med 40 (2) : 339 ~ 346

Chung JK / 2004 / Comparison of 18F-fluorodeoxyglucose uptake with glucose transporter-1 expression and proliferation rate in human glioma and non-small-cell lung cancer / N

Davies L / 2006 / Increasing incidence of thyroid cancer in the United States. 1973-2002 / JAMA 295 (18) : 2164 ~ 2167

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