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Background and Objectives:First bite syndrome is the development of pain in the parotid region after the first bite of each meal and can be sen after surgery of the parapharyngeal space tumor. The purpose of this study is to report the incidence and Subjects and Method:A retrospective review was done on 22 patients diagnosed and surgicaly treated for tumors of the parapharyngeal space from May 2001 to Sep-tember 2005. Results:Seven of 22 patients were diagnosed with the first bite syndrome after the operation of the parapharyngeal space tumor. In postoperative pathology, three were pleomorphic adenoma of parotid gland, three were paraganglioma of carotid body, and remaining one was schwannoma originated from sympathetic nerve chain. The first bite syndrome developed in 1 out ial artery, and all thre patients with paraganglioma, originated from carotid body. The pain subsided in one patient 3 months after the development of first bite syndrome, although the pain persisted in remaining 6 patients during follow-up period. Conclusion:First bite syndrome is a minor complication of surgery involving the parapharyngeal space. But symptoms are often mild but can be severe enough to hinder a patients quality of life and ability to eat. Therefore, surgeons who operate in the parapharyngeal (Korean J Otolaryngol 2007 ;50 :59-63)

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