Prognostic Value of Volume-Based Positron Emission Tomography/Computed Tomography in Patients With Nasopharyngeal Carcinoma Treated With Concurrent Chemoradiotherapy

최준영; 이환주; 손영익; 백정환; 안용찬; 안명주; 박근칠; 문승환; 김병태

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자료유형: 학술저널

저자정보: 최준영 이환주 손영익 백정환 안용찬 안명주 박근칠 문승환 김병태

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제8권 제2호

발행연도: 2015.1

수록면: 142 - 148 (7page)

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Objectives. The aim of this study was to evaluate the prognostic value of volume-based metabolic parameters measured by18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in patients with nasopharyngeal carcinoma(NPC). Methods. Forty-four NPC patients who underwent 18F-FDG PET/CT for initial staging work-up before concurrent chemoradiotherapy(CCRT) were retrospectively evaluated. Maximum standardized uptake value (SUV), mean SUV, metabolictumor volume (MTV), and total lesion glycolysis (TLG) of the primary tumors were measured. The prognosticsignificance and predictive performance of these parameters were assessed by Cox proportional hazards regressionanalysis and time-dependent receiver operating characteristics (ROC) curve analysis. Results. Multivariate analysis showed that American Joint Committee on Cancer stage 7th edition (hazard ratio [HR],1.525; 95% confidence interval [CI], 1.062 to 2.188; P=0.022), and TLG (HR, 7.799; 95% CI, 2.622 to 23.198; P≤0.001) were independent predictive factors associated with decreased disease-free survival (DFS). Time-dependentROC curve analysis indicated that TLG was a better predictor of DFS than MTV (P=0.008). Conclusion. The TLG of the primary tumor was a significant independent metabolic prognostic factor of DFS in patientswith NPC treated with CCRT.

#Fluorodeoxyglucose F18 #Positron-Emission Tomography #Nasopharyngeal Carcinoma #Tumor Burden #Prognosis

참고문헌 (21)

참고문헌 신청

Al-Sarraf M / 2002 / Nasopharyngeal carcinoma / Curr Treat Options Oncol 3 (1) : 21 ~ 32

Allal AS / 2004 / Dulguerov P. Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F]fluoro-2-deoxy-D-glucose / Int J Radiat O

Bum Soo Kim / 2011 / The Prognostic Value of the Metabolic Tumor Volume in FIGO stage IA to IIB Cervical Cancer for Tumor Recurrence: Measured by F-18 FDG PET/CT / Nuclear M

Chan SC / 2009 / Prediction for distant failure in patients with stage M0 nasopharyngeal carcinoma: the role of standardized uptake value / Oral Oncol 45 (1) : 52 ~ 58

Farias TP / 2003 / Prognostic factors and outcome for nasopharyngeal carcinoma / Arch Otolaryngol Head Neck Surg 129 (7) : 794 ~ 799

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