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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제6권 제1호
- 발행연도
- 2013.1
- 수록면
- 1 - 6 (6page)
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초록· 키워드
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Objectives. This experimental study investigated the possible protective effect of beta glucans on amikacin ototoxicity.
Methods. Thirty-eight rats with normal distortion product otoacoustic emissions (DPOAEs) were divided into four groups. Group K was the control group. Group A was injected intramuscularly (i.m.) with amikacin 600 mg/kg/day between days 1-15. Group AB was given beta glucan gavage 1 mg/kg/day on days 0-15 and given amikacin 600 mg/kg/day i.m. on days 1-15. Group B was administered only beta glucan gavage, 1 mg/kg/day, on days 0-15. The DPOAEs were elicited in different frequency regions between 2,003 and 9,515 Hz, as distortion product diagrams (DPgrams), before and after the medication was administered, in all groups, on days 1, 5, 10, and 15.
Results. No significant changes in the DPgrams were observed in group K. In group A, significant deterioration was observed at the 8,003 and 9,515 Hz frequencies on day 10, and at the 3,991, 4,557, 5,660, 6,726, 8,003, and 9,515 Hz frequencies on day 15. For group AB, statistically significant deterioration was observed at the 2,824, 8,003, and 9,515 Hz frequencies on day 15. The results for group B showed a significant improvement of hearing at the 2,378, 2,824, 3,363, and 3,991 Hz frequencies on day 1, at the 3,363, 3,991, and 8,003 Hz frequencies on day 10, and at the 8,003 Hz frequency on day 15.
Conclusion. This study suggests that amikacin-induced hearing loss in rats may be limited to some extent by concomitant use of beta glucan.
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참고문헌 (26)
참고문헌 신청
Abdollahi M / 2003 / Increasing intracellular cAMP and cGMP inhibits cadmium-induced oxidative stress in rat submandibular saliva / Comp Biochem Physiol C Toxicol Pharmacol
Brown GD / 2001 / Immune recognition: a new receptor for beta-glucans / Nature 413 (6851) : 36 ~ 37
Cheeseman KH / 1993 / An introduction
Dai CF / 2006 / Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo / Hear Res 213 (1-2) : 64 ~ 78
Dulon D / 1993 / Pharmacokinetics of gentamicin in the sensory hair cells of the organ of Corti: rapid uptake and long term persistence / C R Acad Sci III 316 (7) : 682 ~ 687
Brown GD / 2001 / Immune recognition: a new receptor for beta-glucans / Nature 413 (6851) : 36 ~ 37
Cheeseman KH / 1993 / An introduction
Dai CF / 2006 / Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo / Hear Res 213 (1-2) : 64 ~ 78
Dulon D / 1993 / Pharmacokinetics of gentamicin in the sensory hair cells of the organ of Corti: rapid uptake and long term persistence / C R Acad Sci III 316 (7) : 682 ~ 687
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