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곽민영; 유광규; 강용경; 윤상원; 심현준; 안용휘

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자료유형: 학술저널

저자정보: 곽민영 유광규 강용경 윤상원 심현준 안용휘

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제58권 제1호

발행연도: 2015.1

수록면: 19 - 24 (6page)

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연구방법

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Background and Objectives The effectiveness of intratympanic dexamethasone injections (ITD) alone is compared against the combination therapy of ITD and oral diuretics as treatments for acute low frequency sensorineural hearing loss (LFHL) without vertigo. Subjects and Method A total of 36 patients, with LFHL ≤500 Hz that had been developed within the last 1 month, were enrolled and then were retrospectively categorized into two groups: 1) those treated with ITD four times each day for 4 consecutive days (ITD only group; 19 patients) and 2) those treated with ITD in the same way and diuretics orally for 2 weeks (combination group; 17 patients). After 8 weeks, treatment outcomes were analyzed for LFHL using subjective improvement and audiometric change. Results Hearing thresholds at low frequencies ≤500 Hz were significantly reduced at 8 weeks after treatment in both ITD only and combination group (p＜0.05). The cure rate of the combination group was higher than that of the ITD only group but was not statistically significant (52.9% vs. 42.1%, p＞0.05). For subjective symptoms, there were no statistically significant differences in the improvement rate in either group (combination 58.8% vs. ITD only 63.2%, p＞0.05). In pure tone audiometry, the improvement rate of the combination group was not significantly different from that of the ITD only group (76.5% vs. 73.7%, p＞0.05). There was a significant correlation between the complete recovery rate and duration of symptoms. Conclusion ITD alone is an effective treatment modality for LFHL within 1 month after onset. Diuretics have no additive effect for the recovery of hearing in patients with acute LFHL without vertigo.

#Combination drug therapy #Diuretics #Sensorineural hearing loss #Steroids #Sudden hearing loss

참고문헌 (22)

참고문헌 신청

Alatas N / 2009 / Use of intratympanic dexamethasone for the therapy of low frequency hearing loss / Eur Arch Otorhinolaryngol 266 (8) : 1205 ~ 1212

An YH / 2014 / Intratympanic steroid treatment for acute low frequency sensorineural hearing loss without vertigo: prospective controlled study / Tinnitus Research Initiative, Proc

An YH / 2014 / Prognostic factors for the outcomes of intratympanic dexamethasone in the treatment of acute subjective tinnitus / Otol Neurotol 35 (8) : 1330 ~ 1337

Bespalova IN / 2001 / Mutations in the Wolfram syndrome 1 gene (WFS1) are a common cause of low frequency sensorineural hearing loss / Hum Mol Genet 10 (22) : 2501 ~ 2508

Canale A / 2005 / The prognostic value of the otoacoustic emission test in low frequency sudden hearing loss / Eur Arch Otorhinolaryngol 262 (3) : 208 ~ 212

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