지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 403 - 409 (7page)
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Unlike most thyroid cancers which have an excellent prognosis with standard treatments such as surgery and additional radioactive iodine therapy followed by long term TSH suppression, 15-20% of differentiated thyroid cancers are unresponsive, showing locally aggressive behavior or distant metastasis. It has been reported that the ability of iodine uptake among residual follicular cells is usually impaired in such unresponsive cases. As the general incidence of thyroid cancer increases, the number of this radioactive iodine refractory disease is also increasing. This becomes clinically challenging because iodine-based diagnostic and therapeutic approaches are not applicable anymore. Moreover, other conventional modalities including radiotherapy or cytotoxic chemotherapy is neither effective in this subset of thyroid cancer. So many researches are currently under way to find effective molecular targeted therapies, which will play a role in the treatment of these unresectable and advanced cases. This review discusses the recent research progress regarding the iodine avidity of follicular cells in thyroid cancer, and outcomes of clinical studies using targeted agents.
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참고문헌 (21)
참고문헌 신청
Caillou B / 1998 / Na+/I- symporter distribution in human thyroid tissues: an immunohistochemical study / J Clin Endocrinol Metab 83 (11) : 4102 ~ 4106
Castro MR / 2001 / Immunohistochemical analysis of sodium iodide symporter expression in metastatic differentiated thyroid cancer: correlation with radioiodine uptake / J Cl
Durante C / 2006 / Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy / J C
Eustatia-Rutten CF / 2006 / Survival and death causes in differentiated thyroid carcinoma / J Clin Endocrinol Metab 91 (1) : 313 ~ 319
Faggiano A / 2007 / Functional characterization of human thyroid tissue with immunohistochemistry / Thyroid 17 (3) : 203 ~ 211
Castro MR / 2001 / Immunohistochemical analysis of sodium iodide symporter expression in metastatic differentiated thyroid cancer: correlation with radioiodine uptake / J Cl
Durante C / 2006 / Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy / J C
Eustatia-Rutten CF / 2006 / Survival and death causes in differentiated thyroid carcinoma / J Clin Endocrinol Metab 91 (1) : 313 ~ 319
Faggiano A / 2007 / Functional characterization of human thyroid tissue with immunohistochemistry / Thyroid 17 (3) : 203 ~ 211
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