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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 1 - 7 (7page)
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It has long been known that the major irreversible toxicity of aminoglycosides is ototoxicity. Among them, streptomycin and gentamicin are primarily vestibulotoxic, whereas amikacin, neomycin, dihydrosterptomycin, and kanamicin are primarily cochleotoxic. Cochlear damage can produce permanent hearing loss, and damage to the vestibular apparatus results in dizziness, ataxia, and/or nystagmus. Therefore the cellular mechanisms of aminoglycoside ototoxicity continue to be an active topic of research. Aminoglycosides appear to generate free radicals within the inner ear and activation of the c-Jun N-terminal kinase. These changes lead to the release of cytochrome-c from mitochondria, activation of caspases and nucleases and appearance of pyknotic nuclei in hair cells with subsequent permanent damage to sensory cells and neurons, resulting in permanent hearing loss. Also two mutations in the mitochondrial 12S ribosomal RNA gene have been previously reported to predispose carriers to aminoglycoside induced ototoxicity. Over the years, understanding of the antimicrobial as well as ototoxic mechanisms of aminoglycosides has increased. Nevertheless, proven clinical methods for the prevention of ototoxic injury are not yet available. I reviewed these mechanisms in regard to established and potential future targets.
Korean J Otorhinolaryngol-Head Neck Surg 2012;55:1-7
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참고문헌 (26)
참고문헌 신청
Bryan LE / 1977 / Van Den Elzen HM. Effects of membrane-energy mutations and cations on streptomycin and gentamicin accumulation by bacteria: a model for entry of streptomyci
Chen J / 2007 / Maternally inherited aminoglycoside-induced and nonsyndromic hearing loss is associated with the 12S rRNA C1494T mutation in three Han Chinese pedigrees / Ge
Corey DP / 1979 / Ionic basis of the receptor potential in a vertebrate hair cell / Nature 281 (5733) : 675 ~ 677
Cortopassi G / 1994 / A molecular and cellular hypothesis for aminoglycoside-induced deafness / Hear Res 78 (1) : 27 ~ 30
Cox EC / 1964 / Streptomycin action and the ribosome / Proc Natl Acad Sci U S A 51 : 703 ~ 709
Chen J / 2007 / Maternally inherited aminoglycoside-induced and nonsyndromic hearing loss is associated with the 12S rRNA C1494T mutation in three Han Chinese pedigrees / Ge
Corey DP / 1979 / Ionic basis of the receptor potential in a vertebrate hair cell / Nature 281 (5733) : 675 ~ 677
Cortopassi G / 1994 / A molecular and cellular hypothesis for aminoglycoside-induced deafness / Hear Res 78 (1) : 27 ~ 30
Cox EC / 1964 / Streptomycin action and the ribosome / Proc Natl Acad Sci U S A 51 : 703 ~ 709
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