Relapsing polychondritis is a rare multisystem disorder of unknown etiology characterized by episodic recurrent inflammation and degeneration of cartilage and connective tissue. Autoantibodies against cartilaginous collagen may play a crucial role in the pathogenesis of the disease. Laryngotracheobronchial involvements are rare but the most severe manifestations of the diseases. Although uncommon, this disease should be noted and included in a differential diagnosis in patients who complain of difficulty breathing. Along with a review of the related literatures, we report here on an unusual case of bilateral vocal cord immobility as an initial manifestation of relapsing polychondritis.