병아리 배아에서 겐타마이신 주입 후 발생한내림프낭의 형태학적 변화

이주형; 차흥억; 하종수; 김동영; 이윤규; 한규철

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자료유형: 학술저널

저자정보: 이주형 차흥억 하종수 김동영 이윤규 한규철

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제9호

발행연도: 2005.1

수록면: 1,091 - 1,095 (5page)

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Background and Objectives：Gentamicin, which is known to have potential toxic effect to the inner ear, causes functional disturbance by destroying the inner ear at a concentration above a certain level. The purpose of this study was to identify morphological changes in the endolymphatic sac after gentamicin injection using chick embryo and the degree of changes according to different concentration of gentamicin. Materials and Method：The same breed of chicken (Gallus domesticus) was chosen and artificial growth incubator was used to germinate the eggs. Increasing the concentration of gentamicin at the same rate (10, 20, 30, 40 mg/ml), we injected it into the yolk sac of chicken and observed the morphological changes in the embryonic sac by light microscope. Results：As the concentration of gentamicin increased, the size of the endolymphatic sac increased and the thickness and contour of sac wall changed. Especially, the inner membrane thinned down greatly. Conclusion：In this research, we confirmed that endolymphatic sac is affected by gentamicin in proportion to its concentration. Especially, considering that inner membrane epithelial cells play an important role in the absorption of endolymph, we suggest that the ototoxicity of gentamicin causes the disturbance in the absorption of endolymph, which may cause endolymphatic hydrops.

#병아리·배아·겐타마이신·내림프낭. #Chick·Embryo·Gentamicin·Endolymphatic sac.

참고문헌 (15)

참고문헌 신청

/ / Experimental blockage of the endolymphatic duct andsac and its effect on the inner ear of the guinea pig A study on endolymphatichydrops : 664 ~ 87

/ / Ten years of experience with intratympanicallyapplied streptomycin in the therapy of Morbus Meniere : 149 ~ 52

/ / and function of dark cells in thevestibular labyrinth : 542 ~ 61

/ 1951 / A series of normal stages in the development of thechick embryo 88 : 49 ~ 67

/ 1982 / Animal models of endolymphatic hydrops 3 : 447 ~ 51

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