지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제4권 제2호
- 발행연도
- 2011.1
- 수록면
- 83 - 87 (5page)
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초록· 키워드
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Objectives. Currently established first line therapy of acute (presumed bacterial) rhinosinusitis (ARS) consists of 10 to 14 days of oral amoxicillin or cephalosporins. This study compared the clinical efficacy and tolerance of cefcapene pivoxil (CP) and amoxicillin-clavulanate (AMC) in patients with ARS.
Methods. A randomized, open labeled, double-blinded trial of ARS patients over 15 years of age was performed. Patients diagnosed with ARS received paranasal sinus X-rays and nasal endoscopies and 2 weeks of either CP (150 mg, 3 times/ day) or AMC (625 mg, amoxicillin 500 mg, 3 times/day). All patients revisited the clinic on days 7, 14, and 28 for evaluation of changes in symptoms, endoscopy, and monitoring of any adverse reactions. Demographics, clinical characteristics and drug efficacy were also compared between the two groups.
Results. Among the 60 initially enrolled patients (CP 30, AMC 30), 5 patients in the CP group and 6 in the AMC group were excluded due to poor compliance. There were no significant differences in demographic data including age, sex, initial signs and symptoms, endoscopic and X-ray findings between the two groups. Rates of improvement after 2 weeks were 96% and 95.8% in the CP and AMC group, respectively. Sinus symptoms were changed significantly after 2 and 4 weeks, however, there was no difference between groups (P=0.41). The most common adverse reaction was gastrointestinal complication, diarrhea occurred in 1 patient in the CP group and 6 in the AMC group (P=0.04).
Conclusion. CP and AMC were both effective in treating ARS. The difference of treatment outcome was not found between the two groups, however, gastrointestinal complications were less prevalent in the CP group
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참고문헌 (14)
참고문헌 신청
Anon JB / 2004 / Antimicrobial treatment guidelines for acute bacterial rhinosinusitis / Otolaryngol Head Neck Surg 130 (1) : 1 ~ 45
Anon JB / 2006 / Efficacy/safety of amoxicillin/clavulanate in adults with bacterial rhinosinusitis / Am J Otolaryngol 27 (4) : 248 ~ 254
Benninger MS / 2006 / Endoscopically directed middle meatal cultures versus maxillary sinus taps in acute bacterial maxillary rhinosinusitis: a meta-analysis / Otolaryngol H
Bottenfield GW / 1998 / Safety and tolerability of a new formulation (90 mg/kg/day divided every 12 h) of amoxicillin/clavulanate (Augmentin) in the empiric treatment of ped
Garbutt JM / 2001 / A randomized, placebo-controlled trial of antimicrobial treatment for children with clinically diagnosed acute sinusitis / Pediatrics 107 (4) : 619 ~ 625
Anon JB / 2006 / Efficacy/safety of amoxicillin/clavulanate in adults with bacterial rhinosinusitis / Am J Otolaryngol 27 (4) : 248 ~ 254
Benninger MS / 2006 / Endoscopically directed middle meatal cultures versus maxillary sinus taps in acute bacterial maxillary rhinosinusitis: a meta-analysis / Otolaryngol H
Bottenfield GW / 1998 / Safety and tolerability of a new formulation (90 mg/kg/day divided every 12 h) of amoxicillin/clavulanate (Augmentin) in the empiric treatment of ped
Garbutt JM / 2001 / A randomized, placebo-controlled trial of antimicrobial treatment for children with clinically diagnosed acute sinusitis / Pediatrics 107 (4) : 619 ~ 625
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