지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제4권 제2호
- 발행연도
- 2011.1
- 수록면
- 88 - 94 (7page)
이용수
초록· 키워드
오류제보하기
Objectives.
To investigate expressions of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs)in squamous cell carcinoma of the tonsil and to correlate expression profiles with clinicopathological characteristics.
Methods. Paraffin blocks were obtained from 45 tonsil squamous cell carcinoma (SCC) patients, who underwent surgery as an initial treatment between 1994 and 2004, and from 20 normal controls. Expressions of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 were investigated immunohistochemically.
Results. The expressions of MMPs (except MMP-2) and TIMPs were found to be significantly different in tonsil SCC and normal control tissues. Furthermore, MMP-13 expression was found to be correlated with tumor invasion (P=0.05), and the expressions of MMP-9 and TIMP-1 with nodal metastasis (P=0.048, 0.031). No relation was found between MMP or TIMP expression and recurrence. However, MMP-9 expression was found to be significantly associated with 5-year survival in tonsil SCC patients by multivariate analysis (hazard ratio, 3.853; P=0.013).
Conclusion. Significant overexpressions of multiple MMPs and TIMPs were found in tonsil SCC tissues. Furthermore, our findings suggest that MMP-9 expression might be a useful prognostic factor.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Burian M / 1999 / Angiogenic factors in laryngeal carcinomas: do they have prognostic relevance / Acta Otolar 119 (2) : 289 ~ 292
Cazorla M / 1998 / Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx / J Pathol 186 (2) : 144 ~ 150
Charous SJ / 1997 / Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in head and neck squamous cell carcinoma / Ann Otol Rhinol Laryngol 106
Dunne AA / 2005 / Influence of matrix metalloproteinase 9 (MMP-9) on the metastatic behavior of oropharyngeal cancer / Anticancer Res 25 (6B) : 4129 ~ 4134
Gorogh T / 2006 / Metalloproteinases and their inhibitors: influence on tumor invasiveness and metastasis formation in head and neck squamous cell carcinomas / Head Neck 28 (
Cazorla M / 1998 / Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx / J Pathol 186 (2) : 144 ~ 150
Charous SJ / 1997 / Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in head and neck squamous cell carcinoma / Ann Otol Rhinol Laryngol 106
Dunne AA / 2005 / Influence of matrix metalloproteinase 9 (MMP-9) on the metastatic behavior of oropharyngeal cancer / Anticancer Res 25 (6B) : 4129 ~ 4134
Gorogh T / 2006 / Metalloproteinases and their inhibitors: influence on tumor invasiveness and metastasis formation in head and neck squamous cell carcinomas / Head Neck 28 (
이 논문의 저자 정보
최근 본 자료
댓글(0)
0