고실 내 저농도 젠타마이신 주입술을 통한 메니에르병의 치료

권민수; 이성부; 안중호; 윤태현; 정종우

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자료유형: 학술저널

저자정보: 권민수 이성부 안중호 윤태현 정종우

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제4호

발행연도: 2009.1

수록면: 322 - 326 (5page)

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연구주제

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연구배경

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연구방법

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연구결과

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Background and Objectives：Intratympanic gentamicin injection is used as one of the treatment modalities for medically intractable Meniere’s disease. But the ideal dosage and concentration of gentamicin were not established in consideration of therapeutic efficacy and the risk of postoperative hearing loss. We analyzed the clinical outcome of low-concentration intratympanic gentamicin injection in patients with Meniere’s disease. And we also tried to find factors anticipating for the response to treatment. Subjects and Method：A retrospective review was conducted on 45 subjects who had been diagnosed as ‘definite’ Meniere’s disease (AAO-HNS, 1995) and had no response to medical treatment over 3 months in our clinic. The concentration of gentamicin was 7 mg/cc, which was very low compared with previous studies. We reviewed postoperative changes on vertigo, tinnitus and hearing by questionnaire and pure tone audiometry. We also analyzed preoperative patients’ characteristics for acquisition of predictive factors of treatment response. Results：Vertigo was completely disappeared in 37 (82%) patients and there was no vertigo improvement in 8 (18%) patients despite multiple injections. Tinnitus was controlled in 11 (24%) patients, and aggravated in 4 (8%) patients. A significant postoperative hearing loss over 10 dB occurred in only 6 (13%) patients. Preoperative patients’ hearing threshold, frequency of vertigo, functional level and finding in electrical test, such as electrocochleogram, were not different regarding treatment response. Conclusion：Low-concentration gentamicin was enough to control vertigo and could reduce the risk of postoperative hearing loss in patients with Meniere’s disease.

#메니에르병·젠타마이신 #Meniere's disease·Gentamicin

참고문헌 (22)

참고문헌 신청

Banerjee AS / 2006 / Intratympanic gentamicin for Meniere’s disease: Effect on quality of life as assessed by glasgow benefit inventory / J Laryngol Otol 120 (10) : 827 ~ 83

Beck C / 1978 / Ten years experience with intratympanically applied streptomycin (gentamicin) in the therapy of morbus Meniere / Arch Otorhinolaryngol 221 (2) : 149 ~ 152

Bertino G / 2006 / Intratympanic gentamicin in monolateral Meniere’s disease: Our experience / Eur Arch Otorhinolaryngol 263 (3) : 271 ~ 275

Blakley BW / 2000 / Update on intratympanic gentamicin for Meniere’s disease / Laryngoscope (110) : 236 ~ 240

Cho SL / 1997 / Clinical significance of extratympanic electrocochleography / Korean J Otolaryngol-Head Neck Surg 40 (4) : 531 ~ 536

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