실험적으로 유발한 기니픽 난청모델에서 청각피질과 시각피질의 c-fos 면역반응력 변화

박용호; 김수일; 박재용; 구본석; 김용민; 나기상

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자료유형: 학술저널

저자정보: 박용호 김수일 박재용 구본석 김용민 나기상

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제7호

발행연도: 2008.1

수록면: 602 - 608 (7page)

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Recently, functional studies for auditory cortex are being watched with interest in accordance with development of many radiologic equipments and surgical devices for sensorineural hearing loss. Moreover, it is well known that the function of central auditory pathway is essential for hearing rehabilitation. There are some papers that reported about the functional or metabolic changes of auditory cortex in deafness and in patients with cochlear implantation. The aim of this study was to investigate indirectly the metabolic changes of primary auditory cortex and visual cortex in the c-fos immunoreactivity in an experimentally induced permanent threshold shift animal model. Materials and Method：Ototoxic drugs (kanamycin and furosemide) and noise were used for the induction of permanent threshold shift. Cochlear damages were evaluated with auditory brainstem responses (ABR) and morphologic studies. The c-fos immunoreactivity was observed with a lapse of time after deafening. Results：After the administration of ototoxic drugs and noise exposure, ABR threshold shifts were not recovered until after three months. Cochlear damages were observed in broad areas of cochlea. The c-fos immunoreactivity in the primary auditory cortex was increased during the acute period but it was decreased after one month. In addition, it was recovered again within the level of control three months later. In the visual cortex, increased and sustained immunoreactivities were observed after the drug and noise exposure. Conclusion：This result shows the plasticity of auditory cortex and possibility of some kinds of auditory-visual cross modal plasticity. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:602-8)

#c-fos·Auditory cortex·Visual cortex·Deafness.

참고문헌 (20)

참고문헌 신청

Ahn SH / 2004 / Changes of 2-deoxyglucose uptake in the rat auditory pathway after bilateral ablation of the cochlea / Hear Res 196 (1) : 33 ~ 38

Calvert GA / 1997 / Campbell R, Willams SC, McGuire PK, et al. Activation of auditory cortex during silent lipreading / Science 276 (5312) : 593 ~ 596

Finney EM / 2001 / Visual stimuli activate auditory cortex in deaf / Nat Neurosci 4 (12) : 1171 ~ 1173

Gougoux F / 2004 / Neuropsychology: Pitch discimination in the early blind / Nature 430 (6997) : 309 ~

Hammes DM / 2002 / Early identification and cochlear implantation: Critical factors for spoken language development / Ann Otol Rhinol Laryngol Suppl 189 : 74 ~ 78

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Yong Ho Park

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주요연구분야 의약학 > 의학 일반 의약학 > 임상의학 > 이비인후과학

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