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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 641 - 645 (5page)
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초록· 키워드
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Background and Objectives：The proto-oncogene c-KIT encodes a receptor tyrosine kinase (KIT) whose ligand is a stem cell factor. KIT is expressed and critical for the development and growth of mast cells, melanocytes, hematopoetic stem cells, and the interstitial cells of Cajal. In this study, c-kit gene mutations were analyzed in 27 cases of NK/T cell lymphoma. Subjects and Methods：During 1995 to 2002, 27 patients with NK/T cell lymphoma in the head and neck area were selected for this study. The nasal cavity were predominant sites (15 cases), followed by 6 nasopharynx cases, 4 tonsil 4 cases, and 2 hard palate cases. Gene mutation was analyzed by PCR-SSCP and direct sequencing. Results：c-kit gene mutation was found in 5 of 27 cases by the PCR-SSCP method. Among the 5 cases, 2 cases exhibited no mutation by direct sequencing. Consequently, the mutation of c-kit gene was detected in 3 of 27 cases. Conclusion：The frequency of c-kit gene mutation (11%) indicated in the present cases is lower than that reported in north China but higher than that in Japan.
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등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
/ / Lethal midline granuloma in Seoul : 673 ~ 4
/ / Nation-wide study of lethal midline granuloma in Japan Frequencies of Wegener's granulomatosis : 63 ~ 6
/ 1966 / Primary lymphoma of the nose including a relationship to lethal midline granuloma 112 : 597 ~ 605
/ 1984 / Pathologic and clinical spectrum of post-thymic T-cell malignancy 2 : 413 ~ 26
/ 1989 / Lymphomatoid granulomatosis and angiocentric lymphoma:A spectrum of post-thymic T-cell proliferation 10 : 167 ~ 72
/ / Nation-wide study of lethal midline granuloma in Japan Frequencies of Wegener's granulomatosis : 63 ~ 6
/ 1966 / Primary lymphoma of the nose including a relationship to lethal midline granuloma 112 : 597 ~ 605
/ 1984 / Pathologic and clinical spectrum of post-thymic T-cell malignancy 2 : 413 ~ 26
/ 1989 / Lymphomatoid granulomatosis and angiocentric lymphoma:A spectrum of post-thymic T-cell proliferation 10 : 167 ~ 72
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