지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 589 - 595 (7page)
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초록· 키워드
오류제보하기
Background and Objectives：Aminoglycoside antibiotics are toxic to hair cells of the inner ear. Recently, intratympanic gentamicininjection is widely accepted as a treatment modality for Meniere’s disease. Subjects and Method：We treated anesthetizedchinchillas with one injection of gentamicin into the middle ear and made extracellular recordings from afferents afterthree to four weeks. Results：The spontaneous firing rate of regular and irregular afferents was lower (p<0.05) on the treatedside than on the untreated side. The relative proportions of regular, intermediate, and irregular afferents did not change aftertreatment. The majority of the treated afferents did not significantly respond to rotation, and those that did respond had abnormallylow levels of sensitivity. Sensitivity to externally applied galvanic currents was unaffected. Conclusion：These findingssuggest that a single intratympanic gentamicin injection preserves enough hair cell synaptic activity to drive the spontaneousactivity of vestibular afferents, and does not damage the afferent spike initiation zones.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
/ / Effects of intratympanicgentamicin on vestibular afferents and hair cells in the chinchilla
/ / rapid phase of recoveryfrom unilateral vestibular lesion in rat not dependent on survival ofcentral portion of vestibular nerve : 245 ~ 56
/ 182-203 / The vestibularnerve of the chinchilla relation between afferent response propertiesand peripheral innervation patterns in the semicircular canals
/ 1969 / Regional differences in sensitivity of the vestibularsensory epithelia to ototoxic antibiotics 67 : 177 ~ 89
/ 1979 / The penetration of gentamicin and neomycininto perilymph across the round window membrane 87 : 888 ~ 91
/ / rapid phase of recoveryfrom unilateral vestibular lesion in rat not dependent on survival ofcentral portion of vestibular nerve : 245 ~ 56
/ 182-203 / The vestibularnerve of the chinchilla relation between afferent response propertiesand peripheral innervation patterns in the semicircular canals
/ 1969 / Regional differences in sensitivity of the vestibularsensory epithelia to ototoxic antibiotics 67 : 177 ~ 89
/ 1979 / The penetration of gentamicin and neomycininto perilymph across the round window membrane 87 : 888 ~ 91
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