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Background and Objectives:tological changes have been caried out only in animal models. The purpose of this study is to investigate histological changes of Gore-Tex used in nasal augmentation in human. Subjects and Methods:Gore-Tex of 24 patients who underwent nasal aug-mentation using Gore-Tex (non-reinforced shets) 2- 36 months ago and had re-operated for the sole cosmetic problems was obtained. Histologic examination was performed from specimens including Gore-Tex and the surounding soft tisue with light Results:Histologically, connective tisue ingrowth was observed in all specimen. But the degree of foreign body reaction and colagen deposit varied from specimen to specimen and had no relationship with the dura-tion. Neovascularization was observed from specimen whose duration was longer than 12 months and degenerative calcification was observed from 36 month old specimen. Conclusion:Unlike the findings of previous reports, individual diferences and an implant to be used in human.

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