돌발성 난청에서 아연과 리포프로스타글란딘 E1의 치료 효과 분석

이호윤; 김지찬; 장동식; 최명수; 조진생; 김아영

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자료유형: 학술저널

저자정보: 이호윤 김지찬 장동식 최명수 조진생 김아영

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제58권 제5호

발행연도: 2015.1

수록면: 318 - 323 (6page)

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연구배경

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연구방법

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연구결과

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Background and Objectives We aimed to analyze the therapeutic effect of zinc, lipoprostaglandin E1 in addition to systemic steroid therapy on hearing improvement for the treatment of idiopathic sudden hearing loss. Subjects and Method Retrospective medical chart reviews of 500 patients who had been diagnosed with unilateral idiopathic sudden hearing loss between May 2006 and April 2014 were performed. Then, we conducted a multiple linear regression analysis using the data of individual patients. Results Better hearing gain was associated with low tone hearing loss (p＜0.001), better initial contralateral hearing (p＜0.001), and the absence of dizziness (p=0.015). Patients who underwent intratympanic steroid treatment as salvage treatment showed a lower hearing gain (p＜0.001). Zinc supplementation was effective for the treatment of patients with mild hearing loss (p＜0.001). On the contrary, significant improvements in hearing gain were found in patients with profound hearing loss who were treated with an additional lipoprostaglandin E1 (p＜0.001). Conclusion An additional use of zinc and lipoprostaglandin E1 may enhance hearing improvement for the treatment of idiopathic sudden hearing loss.

#Profound #Prostaglandin #Steroid #Sudden hearing loss

참고문헌 (22)

참고문헌 신청

Ahn JH / 2005 / Therapeutic effect of lipoprostaglandin E1 on sudden hearing loss / Am J Otolaryngol 26 (4) : 245 ~ 248

Cvorovi? L / 2008 / Prognostic model for predicting hearing recovery in idiopathic sudden sensorineural hearing loss / Otol Neurotol 29 (4) : 464 ~ 469

Dallan I / 2010 / Intratympanic methylprednisolone in refractory sudden hearing loss: a 27-patient case series with univariate and multivariate analysis / Otol Neurotol 31 (1

Fetterman BL / 1996 / Prognosis and treatment of sudden sensorineural hearing loss / Am J Otol 17 (4) : 529 ~ 536

Hikita-Watanabe N / 2010 / Tinnitus as a prognostic factor of sudden deafness / Acta Otolaryngol 130 (1) : 79 ~ 83

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