갑상선 수질암의 치료 결과

최윤정; 강대형; 홍종철; 이형신; 김성원; 이강대

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자료유형: 학술저널

저자정보: 최윤정 강대형 홍종철 이형신 김성원 이강대

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제55권 제3호

발행연도: 2012.1

수록면: 166 - 172 (7page)

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Background and Objectives The aim of this study was to evaluate the treatment outcomes of medullary thyroid carcinoma (MTC) by retrospective data analysis. Subjects and Method We conducted a retrospective chart review of 17 cases of pathologically proven MTC patients who were treated from 1998 to 2010 at the department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine. Results The mean tumor size was 2.32 cm (0.5-3.4 cm). Seventy-one percent of patients were diagnosed with advanced stage (III or IV) of MTC. We performed RET genetic screening in 8 of 17 patients. Hereditary MTC was found in 3 of 17 patients (18%) and sporadic MTC was found in 14 of 17 (82%). The preoperative assessment of basal serum calcitonin (CT) level was performed in 15 of 17 patents. Eleven patients had elevated basal calcitonin levels (＞13 pg/mL). After the operation for MTC, the serum CT levels were elevated in 7 patients. Overall 5-year survival rate was 94%. Normalization of serum calcitonin level was accomplished more frequently in the absence of extra thyroidal invasion (p=0.034), multifocal tumor (p=0.02). Conclusion The initial treatment of MTC is total thyroidectomy with central compartment neck dissection with or without lateral neck dissection. To detect recurrence or metastasis, regular checking of serum calcitonin is necessary. A better knowledge of prognostic factors could improve the management of MTC patients.

#Medullary thyroid carcinoma #Treatment

참고문헌 (19)

참고문헌 신청

Barbet J / 2005 / Prognostic impact of serum calcitonin and carcinoembryonic antigen doubling-times in patients with medullary thyroid carcinoma / J Clin Endocrinol Metab 90

Chen H / 1998 / Effective long-term palliation of symptomatic, incurable metastatic medullary thyroid cancer by operative resection / Ann Surg 227 (6) : 887 ~ 895

Cooper DS / 2009 / Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer / Thyroid 19 (11) : 1167 ~

Dralle H / 1995 / The value of lymph node dissection in hereditary medullary thyroid carcinoma: a retrospective, European, multicentre study / J Intern Med 238 (4) : 357 ~ 3

Eng C / 1996 / The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consort