지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 379 - 385 (7page)
이용수
초록· 키워드
오류제보하기
Acoustic tumor is the most common tumor originating from cerebellopontine angle. Acoustic tumor is benign and main origin of this tumor is vestibular nerve. This tumor arises in Schwann cell (SC) and is encapsulated. Recently, the tumor is called vestibular schwannoma (VS). VS is classified to two type by epidemiology, sporadic form and neurofibromatosis type 2 (NF2). NF2 is autosomal dominant inherent disorder. This tumor is characterized bilateral VS, brain tumors such as meningioma and ependymoma, and spinal or cranial nerve schwannoma. Genetic studies suggested that NF2 is caused by abnormality or mutation of NF2 gene in chromosome 22q12. Both of them are known to develop the tumor by mutation of NF2 gene. Merlin is the cytoskeletal protein product of the NF2 tumor suppressor gene that mediates cell to cell contact information to regulate SC proliferation and survival. And merlin is highly homologous to ERM proteins. Merlin function is regulated by its conformation, adopting an inactive, growth permissive state following serine 518 (S518) phosphorylation. In NF2 patients, the precise mechanisms of developing the VS are unclear. But, the abnormalities of merlin are confirmed by many studies. And now, a lot of research about merlin function is progressing. In this study, the author would introduce about merlin (structure, function, molecular pathway, tumorigenesis and regulation) which leads to VS and molecular studies about merlin, and suggest the future direction of research.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Brault E / 2001 / No
Bretscher A / 2000 / ERM-Merlin and EBP50 protein families in plasma membrane organization and function / Annu Rev Cell Dev Biol 16 : 113 ~ 43
Couturier J / 1990 / Assessment of chromosome 22 anomalies in neurinomas by combined karyotype and RFLP analyses / Cancer Genet Cytogenet 45 (1) : 55 ~ 62
Evans DGR / 1992 / A genetic study of type 2 neurofibromatosis in the United Kingdom.Prevalence,mutation rate,fitness and confirmation of maternal transmission effect on seve
Fiedler W / 1991 / New markers for the neurofibromatosis-2 region generated by microdissection of chromosome 22 / Genomics 10 (3) : 786 ~ 791
Bretscher A / 2000 / ERM-Merlin and EBP50 protein families in plasma membrane organization and function / Annu Rev Cell Dev Biol 16 : 113 ~ 43
Couturier J / 1990 / Assessment of chromosome 22 anomalies in neurinomas by combined karyotype and RFLP analyses / Cancer Genet Cytogenet 45 (1) : 55 ~ 62
Evans DGR / 1992 / A genetic study of type 2 neurofibromatosis in the United Kingdom.Prevalence,mutation rate,fitness and confirmation of maternal transmission effect on seve
Fiedler W / 1991 / New markers for the neurofibromatosis-2 region generated by microdissection of chromosome 22 / Genomics 10 (3) : 786 ~ 791
이 논문의 저자 정보
최근 본 자료
댓글(0)
0