두경부암에서 p53, Bcl-2, PCNA, VEGF 발현의 임상적 의의: Cisplatin 항암치료의 감수성 및 예후와의 관계

김용완; 이병주; 이진춘; 박성수; 이재은; 전경명; 왕수건

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자료유형: 학술저널

저자정보: 김용완 이병주 이진춘 박성수 이재은 전경명 왕수건

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제50권 제12호

발행연도: 2007.1

수록면: 1,141 - 1,148 (8page)

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：Many researchers have attempted to correlate tumor marker expresion with the response of chemoradiotherapy and prognosis of head and neck cancer. But no clear markers are available that can predict responses to treatment or survival in head and neck cancer. This study investigates the relationship between tumor marker expressions and prognosis. Subjects and Method：Thirty-eight patients who received cisplatin and 5-fluorouracil (5-FU) chemotherapy for the motherapy and the imunohistochemical expression of p53, Bcl-2, VEGF, PCNA. The relationship between survival and tumor marker expression was evaluated in twenty five patients who received chemotherapy and radiotherapy. Results：Expression rates of p53, Bcl-2, VEGF, PCNA were 65%, 26%, 26%, 68%, respectively. Of the markers examined, while the expression of p53 was associated with chemosensitivity (p= 0.02), other markers was not associated with chemosensitivity (p>0.05). The (p= 0.07), tumor markers and other clinical parameters were not associated with recurrence (p>0.05). Five year survival rate was 60%. The primary site of tumor semed to be aso-ciated with the overall survival rate of (p= 0.07). Any other clinical characteristics and tumor markers were not associated with survival. Conclusion：The expression of p53 may be a clinically useful predictor of chemosensitivity in this group of patients. cancer. (Korean J Otorhinolaryngol-Head Neck Surg 2007 ;50 :1141-8)

#두경부암종·시스플라틴·항암치료감수성·P53·예후. #Head and neck cancer· Cisplatin· Chemosensitivity· p53· Prognosis.

참고문헌 (19)

참고문헌 신청

/ / Expresion of vas-cular endothelial growth factor in laryngeal squamous cel carcinoma

/ / The role of the p53 tumor supressor gene in squamous cell carcinoma of the head and neck

/ 1995 / Overexpresion of p53 predicts organ preservation using induction chemotherapy and radiation in patients with advanced laryngeal cancer 113 (4) : 408 ~ 412

/ 1996 / The dual role of mutant p53 protein in chemosensitivity of human cancers 16 (6B) : 3845 ~ 3848

/ 1998 / Bcl2 and p53 regulate vascular endothelial growth factor (VEGF)-mediated angiogenesis in non-small cell lung carcinoma 34 (5) : 718 ~ 723

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