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Background and Objectives:Vibration-induced nystagmus(VIN) may be a useful bedside sign for detecting vestibular imbalance.However, the clinical significance of VIN remains unclear. The aim of this study is to analyze the lateralizing value of VINin patients with unilateral vestibular deficit after acute vestibular functional loss. Subjects and Method:Forty patients with peripheralvestibular loss of acute etiology were included. Patients assuming fluctuating or slowly aggravating vestibular dysfunctionwere excluded. VIN was induced by applying 100 Hz vibratory stimuli to both mastoids side by side. Direction and intensity of horizontalnystagmus were analyzed by using video-oculography. Post-head shaking nystagmus(HSN), caloric test and vestibularevoked myogenic potential(VEMP) were also performed. Age matched 25 healthy volunteers were included for control. Results:Of the 40 patients, 37(92.5%) showed contralesional VIN whereas only one exhibited ipsilesional nystagmus. Two patients(2.5%)did not develop VIN. Immediate HSN was present in 31(77.5%) patients. VIN and HSN were present in the same direction in24 patients and in the opposite direction in 5. The intensity of VIN showed significant correlations with the intensity of HSN andthe degree of canal paresis on bithermal caloric test, whereas it did not depend on the presence of VEMP. Conclusion:VIN ismostly contralesional in peripheral vestibulopathies. VIN may be a simple and useful clinical sign for indicating lateralization infixed vestibular loss. (Korean J Otolaryngol 2006;49:897-903)

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