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Background and Objectives:Pilomatricoma, also known as calcifying epitheliomas of Malherbe is uncommon, benign skinneoplasm that arise from outer root sheath cell of hair follicle or hair follicle of sebaceous glands. In more than half of the cases,pilomatricoma typically involves the head and neck followed by upper extremities and trunk, with the majority occurring inchildren. The purpose of this study is to analyze the data from the authors experience with head and neck pilomatricoma and todiscuss diagnostic and therapeutic management. Subjects and Method:A retrospective analysis of the patients of pilomatricomatreated between 1994 and 2004 revealed 21 cases of head and neck pilomatricoma. Results:The typical clinicalmanifestation of pilomatricoma was non-tender, firm, subcutaneous, and nodular mass. The age range was from 9 months to 62years (mean 17.4 years). The male-to-female ratio was 4:3. The common sites of occurrence were the neck (33%), cheek(24%), suboccipital (14%), preauricular (14%). The size of the mass ranged from 0.5 cm to 3 cm, and the mean was 1.1 cm. CTwith contrast enhancement scans revealed densely calcified, mild enhancing and well circumscribed soft tissue densities insubcutaneous tissues. Additionally, MRI with gadolinum enhancement scans revealed partially enhanced, well demarcated andintermediate signal intensity mass lesions. Surgical excision was curative in all cases. Conclusion:Pilomatricoma is cutaneousneoplasms that occur commonly in the head and neck region. Even if the preoperative diagnosis may be difficult in some cases,pilomaticoma must be considered in the differential diagnosis of a superficial head and neck mass. (Korean J Otolaryngol2006;49:549-53)

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