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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 594 - 600 (7page)
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Background and Objectives：Expression of HMGI(Y), a nucleoprotein that binds to A/T rich sequences in the minor
groove of the DNA helix, is observed in neoplastically transformed cells but not in normal cells. We have analyzed HMGI
(Y) expression in the head and neck squamous cell carcinoma and evaluated its clinicopathologic significance. Materials
and Methods：HMGI(Y) mRNA was measured by RT-PCR and immunohistochemical staining for HMGI(Y) was performed
in the head and neck squamous cell carcinoma. Results：Expression of HMGI(Y) by immunohistochemical staining
was observed in 35 of 40 (87.5%) head and neck squamous cell carcinoma samples, whereas normal mucosa and/or the
mucosa adjacent to the tumor tissue showed negative or weakly positive staining (p<0.05). Semiquantification of HMGI(Y)
by RT-PCR were 2.98±2.24 in cancer and 0.47±0.25 in normal tissue (p<0.001). High expression of HMGI(Y) was observed
in well differentiated group and recurrent cases compared to the less differentiated group and/or non-recurrent cases
(p<0.05). But no significant correlation was observed between the levels of HMGI(Y) expression and other clinical factors
such as stage, tumor size and cervical lymph node metastasis. Conclusion：We think that the HMGI(Y) gene plays some
roles in carcinogenesis and cellular proliferation of the head and neck squamous cell carcinoma. HMGI(Y) gene can be used
as a cancer marker, but the correlation between the gene expression and the prognosis of the cancer patient should be proved
in the future studies. (Korean J Otolaryngol 2002;45:594-600)
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