스트레스 호르몬과 돌발성 난청과의 관계

강보성; 이현수; 박진수; 배공근; 이병돈; 이지성

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자료유형: 학술저널

저자정보: 강보성 이현수 박진수 배공근 이병돈 이지성

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제57권 제6호

발행연도: 2014.1

수록면: 373 - 378 (6page)

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Background and Objectives The plasma stress-related hormonal [cortisol, growth hormone, prolactin, antidiuretic hormone (ADH), adrenocorticotropic hormone (ACTH)] levels have been reported to be elevated in sudden sensorineural hearing loss (SSNHL) patients. However, little is known regarding the mechanisms related with the elevation of stress-related hormonal levels in SSNHL. Therefore, we measured the level of plasma stress-related hormones in SSNHL patients and in normal persons to demonstrate the association between the stress-related hormones and SSNHL. Subjects and Method Stress-related hormonal levels were measured from 68 patients who were diagnosed with SSNHL. These values were compared with the stress-related hormonal levels of 24 healthy control subjects. Results The plasma ADH levels was significantly higher in SSNHL group compared with that in their normal control group, as shown by their respective values, 4.46 [95% confidence interval (CI): 3.80-5.24 pg/mL] and 3.05 (95% CI: 2.34-3.98 pg/mL). The values for plasma cortisol, growth hormone, and ACTH levels whose values were 2.07 (95% CI: 1.65-2.61 μg/L), 0.20 (95% CI: 0.14-0.29 μg/L), and 12.79 (95% CI: 11.16-14.66 pg/mL), respectively, were significantly lower in the SSNHL group than those in the normal control group whose values were 7.86 (95% CI: 5.33-5.24 μg/L), 0.61 (95% CI: 0.36-1.04 μg/L), 18.48 (95% CI: 14.99-22.78 pg/mL), respectively. But there was no significant difference in prolactin between the two groups. Conclusion This study demonstrates a possible role of stress-related hormones in the pathogenesis of SSNHL. However, only ADH level was higher than the control group. Furthermore, ACTH, growth hormone and cortisol levels were lower than the control groups. This means ADH, growth hormone, cortisol, ACTH levels are related with SSNHL. However, the impact of this hormone on the inner ear and endolymph homeostasis is still unknown. Further investigation is necessary to identify the action mechanism of these hormones in the inner ear. Korean J Otorhinolaryngol-Head Neck Surg 2014;57(6):373-8

#SSNHL #Stress

참고문헌 (21)

참고문헌 신청

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