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Background and Objectives Infection of congenital preauricular fistula leads to preauricular abscess. Generally, the treatment for preauricular abscess is focused on subsiding abscess. Although incision & drainage is major point of therapy, the study of bacterial species and antibiotics for preauricular abscess is scant in literature. So, we investigated the most common species that cause preauricular abscess and the choice of proper antibiotics by using the databse available from the last 10 years. Subjects and Method Our studies, from January, 2000 to December, 2010, included 86 patients in total (all in patients & out patients). We performed a retrospective review of bacterial species and culture analysis of each preauricular abscess. Results In this study, it was shown that most common pathogens causing preauricular fistula infection were Staphylococcus (27.9%), Enterococcus (9.3%), streptococcus and Klebsiella (5.8%) and Peptostreptococcus (4.6%). And Amoxicillin/cavulanate, Ciprofloxacin, Clindamycin had excellent effects of minimal inhibitory concentration through multiple pathogens. Conclusion The choice of antibiotics for preauricular abscess will be targeted on Staphylococcus, Enterococcus, Streptococcus and anaerobic infection. Amoxicillin/clavulanate or Ciprofloxacin are the most effective antibiotics.

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