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Adenoic cystic carcinoma (ACC) is a malignant tumor, occuring in the major and minor salivary glands. Laryngeal ACC is a rare malignancy that constitutes less than 1% of all laryngeal malignancies. ACC is characterized by slow growth, multiple recurrences and late distant metastasis. The treatment of the ACC is by wide excision or by combining wide excision with postoperative radiotherapy. A 33-year-old woman, who had been diagnosed with epiglottic cyst in 2007, complained of throat discomfort that had been aggravating for the past two weeks. The tumor was treated with transoral laser excision. The pathologic report revealed an adnoid cystic carcinoma on the epiglottis; it was composed of cribriform patterned nests and columns of tumor cells. No recurrence was detected until post-operative 16 months by endoscopic examination. Transoral laser excision was suggested for successful treatment for the adenoid cystic carcinoma.

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