지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 222 - 228 (7page)
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초록· 키워드
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Background and Objectives Hereditary hemorrhagic telangiectasia (HHT), often manifested as epistaxis, is also manifested in combination with serious comorbid diseases. The authors reviewed 12 cases of HHT and investigated the manifestations and comorbid diseases of HHT in the Korean population.
Subjects and Method Medical records of the HHT patients in our department from July 2004 to December 2011 were reviewed retrospectively. Twelve patients who had been classified as definite or possible HHT according to the Curacao criteria were enrolled in this study. Clinical manifestations, treatment methods, results, and comorbid diseases were investigated.
Results Recurrent epistaxis occurred in 100% of the patients. Epistaxis was managed by bipolar or laser cauterization (n=9), embolization of the feeding vessel (n=1), intranasal application of bevacizumab (Avastin®)(n=2) or septodermoplasty (n=1). The symptoms of seven patients showed much improvement while the other two did not. Comorbid diseases included pulmonary arteriovenous malformation (AVM) in 5 patients (41.7%) and cerebral AVM in 2 patients (16.7%). Three patients with pulmonary AVM received embolization and one patient with cerebral AVM received gamma knife surgery with good prognosis.
Conclusion Epistaxis by HHT can be improved by active treatment using various methods. Pulmonary and cerebral AVMs are common comorbid diseases and should be considered in the management of HHT.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
AAssar OS / 1991 / The natural history of epistaxis in hereditary hemorrhagic telangiectasia / Laryngoscope 101 (9) : 977 ~ 980
Bergler W / 2002 / Topical estrogens combined with argon plasma coagulation in the management of epistaxis in hereditary hemorrhagic telangiectasia / Ann Otol Rhinol Laryngo
Chung SK / 1994 / A case of hereditary hemorrhagic telangiectasia / Korean J Otolaryngol Head Neck Surg 37 (1) : 157 ~ 161
Cottin V / 2007 / Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease) / Respiration 74 (4) : 361 ~ 378
Dakeishi M / 2002 / Genetic epidemiology of hereditary hemorrhagic telangiectasia in a local community in the northern part of Japan / Hum Mutat 19 (2) : 140 ~ 148
Bergler W / 2002 / Topical estrogens combined with argon plasma coagulation in the management of epistaxis in hereditary hemorrhagic telangiectasia / Ann Otol Rhinol Laryngo
Chung SK / 1994 / A case of hereditary hemorrhagic telangiectasia / Korean J Otolaryngol Head Neck Surg 37 (1) : 157 ~ 161
Cottin V / 2007 / Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease) / Respiration 74 (4) : 361 ~ 378
Dakeishi M / 2002 / Genetic epidemiology of hereditary hemorrhagic telangiectasia in a local community in the northern part of Japan / Hum Mutat 19 (2) : 140 ~ 148
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