타액관 암종의 임상양상 및 치료결과

정한신; 이현석; 이혁준; 고영혜; 백정환; 손영익

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자료유형: 학술저널

저자정보: 정한신 이현석 이혁준 고영혜 백정환 손영익

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제46권 제4호

발행연도: 2003.1

수록면: 318 - 323 (6page)

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Background and Objectives：Salivary duct carcinoma (SDC) is a rare but highly malignant tumor of the salivary glands. Authors aimed to assess the current treatment outcome and to estimate the prognostic factors in the patients with SDC. Materials and Methods：We reviewed the medical records of 11 patients with SDC, who were treated between Jan. 1995 and Jun. 2002 at the Department of Otolaryngology, Samsung Medical Center. Follow-up duration ranged from 10 to 76 months with a mean of 29.6. Results：The parotid glands were more frequently involved (9 patients) than the submandibular glands (2 patients). Most patients were diagnosed to have an advanced stage of the disease. Curative surgical resections and/or postoperative radiation were the mainstay of the treatment. The adjusted 3-year survival rate was 64.9% and the disease-free 3-year survival rate was 34.1%. Four patients died of the disease at a mean interval of 22 months after the initial diagnosis. Presentation with the facial nerve paralysis, positive surgical resection margins and pathological vascular invasion had a tendency to result in poor survivals. Treatment failures due to distant metastasis were common (54.5%). Conclusion：We reconfirmed the aggressive clinical natures of SDC；frequent distant metastasis and poor survival rates. These findings strongly suggest that additional treatment modalities such as an adjunctive systemic treatment need to be considered in the patients with SDC especially when they have high risk factors or an advanced disease, which need further investigation. (Korean J Otolaryngol 2003;46:318-23)

#타액관·암종·치료결과. #Salivary ducts· Carcinoma· Treatment outcome.

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