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Background and Objectives:The nasopharyngeal cancer (NPC) of nasopharyngeal neoplasms is a rare disease with a rela-treatment of choice. Angiogenesis is a crucial step in the tumor growth and progresion. The authors attempted to investigate the prognostic value of the microvessel density in NPC. Subjects and Method:We analyzed tumor tissues from 57 cases of parafin block specimens which had been diagnosed with NPC and treated at Chonnam National University Hospital. The anti-human von Willebrand factor antibody was used to determine the microvessel density (MVD). Results:The MVD was 48.5 in the early stage (stage I and II) and 51.2 in the advanced stage (stage III and IV), which were not statisticaly significant (p=0.057). The MVD was 55.3 in type I, 54.4 in type II, and 41.8 in type III, and there were no statistical significance betwen these values (p=0.36). The MVD was not statistically significant betwen T and N stages (p=0.26, 0.42). There was no (p>0.05). Conclusion:The results suggest that the MVD was not a prognostic significance in NPC. (Korean J Otolaryngol 2002;45:980-3)

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