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Background and Objectives:This study was designed to compare sinonasal distribution of topical nasal drops and spray according to head positions and to suggest optimal head position for efective topical delivery. Subjects and Methods:The study group included five healthy subjects (normal group) (ESS group). A visual asesment of the intranasal distribution of nasal drops and spray was made using Fluorescein Blue Filter System after instillation of TobraDexdrops and Nasonexdyed with 0.2% fluorescein. Each group took five kinds of head position for nasal drops and two for nasal spray. Results:Drops instilled with head back position were found along the nasal flor, and drops tilled in Mygind position and Ragan position were found in the midle meatus and head of the middle turbinate in the normal group, and in the middle meatus, ethmoidectomized cavity, and maxilary sinus in the ESS group. The head neutral position showed efective dis-tribution to the septum, lateral nasal wal, and midle turbinate in the normal group, and in the ethmoidectomized cavity in the ES group, compared to the head forward position which distributed the drops lower depending portion. Conclusion:These o the olfactory cleft, and Mygind position and Ragan position are proposed to the midle meatal region in non-surgery patients and ethmoidectomized cavity and maxillary sinus in post-ES patients. Head neutral position is recommendable for efective delivery of nasal spray compared to head forward position regardles of ESS.

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