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Background and Objectives:An isolated sphenoid sinus lesion is a rare disorder and is difficult to diagnose for several re-treatments are needed. We experienced 17 cases of isolated sphenoid sinus lesions, including inflammatory, neoplastic, and vascular lesions, and reviewed the clinical findings, radiologic features, treatments and complications of these cases. Materials and Method:Isolated sphenoid sinus lesions were reviewed retrospectively of patients from January 1995 to July 201. Patients were identified with radiologic findings and intraoperative endoscopic findings excluding other paranasal sinus involvements. Results:The most common symptom was headache, and 13 patients (76% ) complained. Nasal symptoms ap-peared only 4 patients (23% ). Pathologic reviews showed 9 cases of acute and chronic sinusitis were 9 cases, 4 fungal sinus-itis, 2 neoplastic diseases, 1 polyp, and 1 vascular disease. We carried out medical treatment in 5 cases, and diagnostic biopsy in 3 cases, and therapeutic surgery in 10 cases. In 7 cases, complications including cranial nerve palsy were observed, and 1 patient was expired due to meningitis. Conclusion:We can diagnose isolated sphenoid sinus lesions exactly with the use of ctively. It is apparent that early recognition and rapid treatment are essential if complications are to be avoided. (Korean J Otolaryngol 2002;45:249-53)

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