지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 30 - 36 (7page)
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초록· 키워드
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Background: This study was conducted to determine the early cardiac valvular changes in young male ankylosing spondylitis (AS) patients.
Methods: A total of 70 AS patients on treatment without clinical cardiac symptoms were divided into group I (< 10 years, n =50) and group II (≥ 10 years, n = 20) depending on their disease duration after first diagnosis. Twenty-five healthy volunteers were selected as control subjects. All the subjects underwent transthoracic and transesophageal echocardiography, electrocardiography, and rheumatologic evaluation for AS patients.
Results: The thickness of both the aortic and mitral valve was more increased in AS patients than in controls. Aortic valve thickness over 1.3 mm could predict AS with a sensitivity of 73% and specificity of 76%. The prevalence of aortic valve thickening was higher in the AS group compared to the controls. The prevalence of aortic and mitral regurgitation was very low and there was no difference between the controls and the patients. The aortic valve thickening was related to longer disease duration, high blood pressure, disease activity and inflammatory markers.
Conclusion: Thickening of the aortic and mitral valve was observed without regurgitation in male AS patients early in the course of their disease without clinical cardiac manifestations. This subclinical change of aorto-mitral valve in early AS should be considered and followed up to determine its prognostic implication and evolution.
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참고문헌 (17)
참고문헌 신청
Arnason JA / 1996 / Transthoracic and transesophageal echocardiographic evaluation of the aortic root and subvalvular structures in ankylosing spondylitis / J Rheumatol 23 :
Braun J / 2007 / Ankylosing spondylitis / Lancet 369 : 1379 ~ 1390
Bulkley BH / 1973 / Ankylosing spondylitis and aortic regurgitation. Description of the characteristic cardiovascular lesion from study of eight necropsy patients / Circulati
Cowling P / 1980 / Association of inflammation with raised serum IgA in ankylosing spondylitis / Ann Rheum Dis 39 : 545 ~ 549
Flachskampf FA / 2010 / European Association of Echocardiography; Echo Committee of the European Association of Cardiothoracic Anaesthesiologists, Roelandt JR, Pieerard L. Re
Braun J / 2007 / Ankylosing spondylitis / Lancet 369 : 1379 ~ 1390
Bulkley BH / 1973 / Ankylosing spondylitis and aortic regurgitation. Description of the characteristic cardiovascular lesion from study of eight necropsy patients / Circulati
Cowling P / 1980 / Association of inflammation with raised serum IgA in ankylosing spondylitis / Ann Rheum Dis 39 : 545 ~ 549
Flachskampf FA / 2010 / European Association of Echocardiography; Echo Committee of the European Association of Cardiothoracic Anaesthesiologists, Roelandt JR, Pieerard L. Re
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