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Background: Aortic banding and debanding models have provided useful information on the development and regression ofleft ventricular hypertrophy (LVH). In this animal study, we aimed to evaluate left ventricular (LV) deformation related to thedevelopment and regression of LVH. Methods: Minimally invasive ascending aorta banding was performed in rats (10 Sprague Dawley rats, 7 weeks). Ten ratsunderwent a sham operation. Thirty-five days later, the band was removed. Echocardiographic and histopathologic analysis wasassessed at pre-banding, 35 days of banding and 14 days of debanding. Results: Banding of the ascending aorta created an expected increase in the aortic velocity and gradient, which normalizedwith the debanding procedure. Pressure overload resulted in a robust hypertrophic response as assessed by gross and microscopichistology, transthoracic echocardiography [heart weight/tibia length (g/m); 21.0 ± 0.8 vs. 33.2 ± 2.0 vs. 26.6 ± 2.8, p < 0.001]. The circumferential (CS) and radial strains were not different between the groups. However, there were significant differences inthe degree of fibrosis according to the banding status (fibrosis; 0.10 ± 0.20% vs. 5.26 ± 3.12% vs. 4.03 ± 3.93%, p = 0.003),and global CS showed a significant correlation with the degree of myocardial fibrosis in this animal model (r = 0.688, p = 0.028). Conclusion: In this animal study, simulating a severe LV pressure overload state, a significant increase in the LV mass indexdid not result in a significant reduction in the LV mechanical parameters. The degree of LV fibrosis, which developed withpressure overload, was significantly related to the magnitude of left ventricular mechanics.

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