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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 273 - 281 (9page)
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The follistatin (FST) gene encodes a monomeric glycoprotein that plays a role in binding and inhibiting the functions of members of the transforming growth factor (TGF)-β superfamily. Thus, FST facilitates a wide variety of functions, ranging from muscle growth, to inflammation and immunity. In this study, we sought to characterize an FST counterpart, RbFST, which was identified from rock bream Oplegnathus fasciatus. The RbFST cDNA sequence (2,419 bp) contains a 933-bp open reading frame (ORF) that encodes a putative amino acid sequence for RbFST (35 kDa). The putative amino acid sequence contains a Kazal-type serine protease inhibitor domain (51-98 residues) and an EF-hand, calcium-binding domain (191-226 residues). Additionally, this sequence shares a high identity (98.7%) with the Siniperca chuatsi FST sequence, with which it also has the closest evolutionary relationship according to a phylogenetic study. Omnipresent distribution of RbFST transcripts were detected in the gill, liver, spleen, head kidney, kidney, skin, muscle, heart, brain, and intestine of healthy animals, with significantly higher expression levels in the heart, followed by the liver tissue. Under pathogenic stress caused by two bacterial pathogens, Streptococcus iniae and Edwardsiella tarda, RbFST transcription was found to be significantly up-regulated. Altogether, our findings suggest the putative role of RbFST in immune related responses against pathogenic infections, further prefiguring its significance in rock bream physiology.
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참고문헌 (30)
참고문헌 신청
Tortoriello DV / 2001 / Human follistatin-related protein : a structural homologue of follistatin with nuclear localization / Endocrinology 142:3426~3434
Tuuri T / 1994 / The tissue distribution of activin beta A-and beta B-subunit and follistatin messenger ribonucleic acids suggests multiple sites of action for the activinfollistatin system during human development / J Clin Endocrinol Metab 78:1521~1524
Umasuthan N / 2014 / Molecular aspects, genomic arrangement and immune responsive mRNA expression profiles of two CXC chemokine receptor homologs(CXCR1 and CXCR2)from rock bream, Oplegnathus fasciatus / Fish & Shellfish Immunology 40:304~318
Welt C / 2002 / Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium / Exp Biol Med (Maywood) 227:724~752
Whang I / 2011 / Characterization and expression analysis of the myeloid differentiation factor 88(MyD88)in rock bream Oplegnathus fasciatus / Mol Biol Rep 38:3911~3920
Tuuri T / 1994 / The tissue distribution of activin beta A-and beta B-subunit and follistatin messenger ribonucleic acids suggests multiple sites of action for the activinfollistatin system during human development / J Clin Endocrinol Metab 78:1521~1524
Umasuthan N / 2014 / Molecular aspects, genomic arrangement and immune responsive mRNA expression profiles of two CXC chemokine receptor homologs(CXCR1 and CXCR2)from rock bream, Oplegnathus fasciatus / Fish & Shellfish Immunology 40:304~318
Welt C / 2002 / Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium / Exp Biol Med (Maywood) 227:724~752
Whang I / 2011 / Characterization and expression analysis of the myeloid differentiation factor 88(MyD88)in rock bream Oplegnathus fasciatus / Mol Biol Rep 38:3911~3920
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