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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 174 - 178 (5page)
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This study aimed to determine the degree of hydrolysis and angiotensin-I-converting enzyme (ACE)-inhibitory activity of Giant Jellyfish Nemopilema nomurai (jellyfish) hydrolysates. The degree of hydrolysis using six proteolytic enzymes (Alcalase, Flavozyme,Neutrase, papain, Protamex, and trypsin) ranged from 13.1-36.8% and the inhibitory activities from 20.46-79.58%. Using papain hydrolysate, we newly isolated and characterized ACE-inhibitory peptides with a molecular weight of 3,000-5,000 Da that originated from jellyfish collagen. The purified peptide (FII-b) was predicted to be produced from an alpha-2 fragment of the type IV collagen of jellyfish. The N-terminal sequence of FII-b was Asp-Pro-Gly-Leu-Glu-Gly-Ala-His-Gly- and showed 87% identity to the collagen type IV alpha-2 fragment of Rattus norvegicus and a predicted protein from Nematostella vectensis, indicating that the ACE-inhibitory peptide originated from the collagen hydrolysate and had an IC_(50) value of 3.8 μg/mL. The primary structure of the fragment is now being studied; this peptide represents an interesting new type of ACE inhibitor and will provide knowledge of the potential applications of jellyfish components as therapies for hypertension.
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참고문헌 (23)
참고문헌 신청
Byun HG / 2001 / Purification and characterization of angiotensin I converting enzyme (ACE) inhibitory peptides from Alaska pollack (Theragra chalcogramma) skin / Process Bio
Cushman DW / 1971 / Spectrophotometeric assay and properties of angiotensin-converting enzyme of rabbit lung / Biochem Pharmacol 20 : 1637 ~ 1648
Dziuba J / 1999 / Biologically active peptides from plant and animal proteins / Pol J Food Nutr Sci 8 : 3 ~ 16
FitzGerald RJ / 2004 / The emerging role of dairy proteins and bioactive peptides in nutrition and health / J Nutr 134 : 980 ~ 988
Fujita H / 1999 / LKPNM:a prodrug-type ACE-inhibitory peptide derived from fish protein / Immunopharmacology 44 : 123 ~ 127
Cushman DW / 1971 / Spectrophotometeric assay and properties of angiotensin-converting enzyme of rabbit lung / Biochem Pharmacol 20 : 1637 ~ 1648
Dziuba J / 1999 / Biologically active peptides from plant and animal proteins / Pol J Food Nutr Sci 8 : 3 ~ 16
FitzGerald RJ / 2004 / The emerging role of dairy proteins and bioactive peptides in nutrition and health / J Nutr 134 : 980 ~ 988
Fujita H / 1999 / LKPNM:a prodrug-type ACE-inhibitory peptide derived from fish protein / Immunopharmacology 44 : 123 ~ 127
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