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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 261 - 265 (5page)
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초록· 키워드
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The study was conducted to investigate the responses of the hepatic microsomal cytochrome P450 monooxygenase system in the rock bream Oplegnathus fasciatus after chronic exposure to 0, 1, 2, 4, and 8 μg/L tributyltin (TBT) concentrations for 4 weeks.
Hepatic cytochrome 450 content and ethoxyresorufin O-deethylation (EROD) activity were found to significantly increase in fish treated with the higher concentration of TBT (≥4 μg/L); however, no significant changes were observed in penthoxyresorufin Odeethylation (PROD) activity in all treated groups compared to the control group. These findings suggest that exposure to a low TBT concentration (≥4 μg/L) has the potential to induce cytochrome 450 content and EROD enzyme activity in hepatic tissue inthe rock bream.
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참고문헌 (31)
참고문헌 신청
Schwaiger J / 1992 / A prolonged toxicity study on the effects of sublethal concentration of bis (tri-n-butyltin) oxide (TBTO): histopathological and histochemical findings in rainbow trout (Oncorhynchus mykiss) / Aquat Toxicol 23:31~48
Skaare JU / 1991 / Response of xenobiotic metabolizing enzymes of rainbow trout (Oncorhynchus mykiss) to the mono-ortho substituted polychlorinated PCB congener 2, 3’, 4, 4’, 5-pentachlorobiphenyl, PCB-118, detected by enzyme activities and immunochemical methods / Arch Environ Contam Toxicol 20:349~352
Stegeman JJ / 1994 / Biochemistry and molecular biology of monooxygenases: Current perspectives on forms, functions, and regulation of cytochrome P450 in aquatic species, In Aquatic Toxicology Molecular Biochemical and Cellular Perspectives / Lewis :87~206
Stegeman JJ / 1990 / Structure, function and regulation of cytochrome P450 forms in fish / Biochem Soc Trans 18:19~21
Tsuda T / 1992 / Accumulation and excretion of tri-n-butyltin chloride and tributyltin chloride by willow shiner / Comp Biochem Physiol 101C:67~70
Skaare JU / 1991 / Response of xenobiotic metabolizing enzymes of rainbow trout (Oncorhynchus mykiss) to the mono-ortho substituted polychlorinated PCB congener 2, 3’, 4, 4’, 5-pentachlorobiphenyl, PCB-118, detected by enzyme activities and immunochemical methods / Arch Environ Contam Toxicol 20:349~352
Stegeman JJ / 1994 / Biochemistry and molecular biology of monooxygenases: Current perspectives on forms, functions, and regulation of cytochrome P450 in aquatic species, In Aquatic Toxicology Molecular Biochemical and Cellular Perspectives / Lewis :87~206
Stegeman JJ / 1990 / Structure, function and regulation of cytochrome P450 forms in fish / Biochem Soc Trans 18:19~21
Tsuda T / 1992 / Accumulation and excretion of tri-n-butyltin chloride and tributyltin chloride by willow shiner / Comp Biochem Physiol 101C:67~70
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