지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 31 - 42 (12page)
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Three novel hepcidin isoforms were isolated and characterized from the perciform fish species Oplegnathus fasciatus. These hepcidin isoforms (designated rbhepc5, rbhepc6 and rbhepc7)were found to share a conserved, tripartite gene structure and a considerable sequence homology one another. A comparison of their mature peptide sequences with those of other perciform hepcidin orthologs indicated that these three hepcidin isoforms as well as four other isoforms previously identified in this species, appear to belong to the HAMP2 group of hepcidin genes.
Analysis of the 5′-upstream sequences showed that the proximal non-coding regions of rbhepc5~7 do not possess canonical TATA signals; instead, they harbor several binding motifs for transcription factors involved in immune modulation. Reverse transcriptase-PCR analysis demonstrated that the rbhepc5~7 are expressed predominantly in the liver, and that the transcription of rbhepc5~7 is rapidly induced in the liver, but not in other tissues, by experimental challenge with any of three different bacterial species. However, transcription of rbhepc6 appeared to be negligible under both basal and stimulated conditions, as judged by the redundancy count of randomly chosen reverse transcriptase-PCR clones.
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참고문헌 (30)
참고문헌 신청
Shike H / 2002 / Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge / Eur J Biochem 269:2232~2237
Tennessen JA / 2005 / Molecular evolution of animal antimicrobial peptides:widespread moderate positive selection / J Evol Biol 18:1387~1394
Tossi A / 2000 / Amphipathic,α-helical antimicrobial peptides / Biopolymers 55:4~30
Truksa J / 2007 / The role of STAT,AP-1,E-box and TIEG motifs in the regulation of hepcidin by IL-6 and BMP-9:Lessons from human HAMP and murine Hamp1 and Hamp2 gene promoters / Blood Cell Mol Dis 39:255~262
Valore EV / 2008 / Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin / Blood Cell Mol Dis 40:132~138
Tennessen JA / 2005 / Molecular evolution of animal antimicrobial peptides:widespread moderate positive selection / J Evol Biol 18:1387~1394
Tossi A / 2000 / Amphipathic,α-helical antimicrobial peptides / Biopolymers 55:4~30
Truksa J / 2007 / The role of STAT,AP-1,E-box and TIEG motifs in the regulation of hepcidin by IL-6 and BMP-9:Lessons from human HAMP and murine Hamp1 and Hamp2 gene promoters / Blood Cell Mol Dis 39:255~262
Valore EV / 2008 / Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin / Blood Cell Mol Dis 40:132~138
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