지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 283 - 288 (6page)
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초록· 키워드
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The jellyfish Nemopilema nomurai was hydrolyzed with papain and a novel dipeptide purified via ultrafiltration, gel filtration chromatography with Sephadex LH-20, and reverse phase chromatography using C_(18) and C_(12) columns. The IR, 1H NMR, 13C NMR, and MS spectrometer analyses showed that the dipeptide comprised tyrosine-isoleucine (Tyr-Ile). The IC_(50) and K_i values were 6.56 ± 1.12 and 3.10 ± 0.28 μM, respectively, indicating competitive inhibition of angiotensin-Ι-converting enzyme (ACE). As a novel ACE-inhibitory active peptide, Tyr-Ile may have potential for use in antihypertensive therapy.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Astawan M / 1995 / Effects of angiotensin-I converting enzyme inhibitory substances derived from Indonesian dried-salted fish on blood pressure of rats / Biosci Biotechnol Bi
Byun HG / 2001 / Purification and characterization of angiotensin I converting enzyme (ACE) inhibitory peptides from Alaska pollack (Theragra chalcogramma) skin / Process Bio
Cheung HS / 1980 / Binding of peptide substrates and inhibitors of angiotensin converting enzyme.Importance of the COOH-terminal dipeptide sequence / J Biol Chem 255 : 401 ~
Cushman DW / 1971 / Spectrophotometeric assay and properties of angiotensin-converting enzyme of rabbit lung / Biochem Pharmacol 20 : 1637 ~ 1648
Dziuba J / 1999 / Biologically active peptides from plant and animal proteins / Pol J Food Nutr Sci 8 : 3 ~ 16
Byun HG / 2001 / Purification and characterization of angiotensin I converting enzyme (ACE) inhibitory peptides from Alaska pollack (Theragra chalcogramma) skin / Process Bio
Cheung HS / 1980 / Binding of peptide substrates and inhibitors of angiotensin converting enzyme.Importance of the COOH-terminal dipeptide sequence / J Biol Chem 255 : 401 ~
Cushman DW / 1971 / Spectrophotometeric assay and properties of angiotensin-converting enzyme of rabbit lung / Biochem Pharmacol 20 : 1637 ~ 1648
Dziuba J / 1999 / Biologically active peptides from plant and animal proteins / Pol J Food Nutr Sci 8 : 3 ~ 16
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