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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 185 - 193 (9page)
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초록· 키워드
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A complete cDNA, which encodes for a myostatin-like protein (Es-MSTN), was isolated from the Chinese mitten crab, Eriocheir sinensis. Es-MSTN was composed of 2,397 nucleotides and the open reading frame (ORF) specified a protein containing 468 amino acids. Es-MSTN exhibited 32% amino acid sequence identity and 52% similarity to human myostatin. Multiple sequence alignment analysis indicated that Es-MSTN possessed the conserved proteolytic cleavage site (RXXR) for maturation of the protein and nine cysteine residues for disulfide bridges. Besides the conserved structural features, Es-MSTN also exhibits its unique characters; a longer N-terminal domain which is involved in protein folding and latent form of myostatin and absence of the cleavage site for BMP-1/tolloid family of metalloproteinase to activate mature myostatin. Phylogenetic analysis suggests that Es-MSTN showed the closely related to both vertebrate myostatin and GDF11. Es-MSTN is expressed highly in the claw muscle, leg muscle, thoracic muscle and heart, and moderately in the hindgut suggesting that Es-MSTN may play important roles in the muscle tissues. As homolog of mammalian myostatin and GDF11, Es-MSTN may be involved in development of muscular tissue and further study will help to produce high-quality seafood.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Allendorph, G.P. / 2006 / Structure of the ternary signaling complex of a TGF-beta superfamily member / Proc. Natl. Acad. Sci. USA 103 : 7643 ~ 7648
El Haj, A.J / 1987 / In vitro and in vivo protein synthesis rates in a crustacean muscle during the moult cycle / J. Exp. Biol. 127 : 413 ~ 426
Esquela, A.F / 2003 / Regulation of me-tanephric kidney development by growth/differen-tiation factor 11 / Dev. Biol. 257 : 356 ~ 370
Forbes, D. / 2006 / Myostatin auto-regulates its expression by feedback loop through Smad7 dependent mechanism / J. Cell. Physiol. 206 : 264 ~ 272
Gad, J.M / 1999 / Axis development: the mouse becomes a dachshund / Curr. Biol. 9 : 783 ~ 786
El Haj, A.J / 1987 / In vitro and in vivo protein synthesis rates in a crustacean muscle during the moult cycle / J. Exp. Biol. 127 : 413 ~ 426
Esquela, A.F / 2003 / Regulation of me-tanephric kidney development by growth/differen-tiation factor 11 / Dev. Biol. 257 : 356 ~ 370
Forbes, D. / 2006 / Myostatin auto-regulates its expression by feedback loop through Smad7 dependent mechanism / J. Cell. Physiol. 206 : 264 ~ 272
Gad, J.M / 1999 / Axis development: the mouse becomes a dachshund / Curr. Biol. 9 : 783 ~ 786
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