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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 323 - 333 (11page)
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초록· 키워드
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Objectives : Zingberis Rhizoma (ZR) and Glycyrrihizae Radix (GR) have been widely used to prevent or treat allergic diseases. However, relatively little research has been conducted on the immune response to Senggang Gamcho-tang (SG) in a mixture of ZR and GR. The purpose of this study was to determine antiallergic effects of Senggang Gamcho-tang (SG) extracts ZR and GR on activity of murine splenocytes.
Methods : This study was performed to investigate the effect of SG in mice, using in vitro experiments. Cells were treated with SG extract (1 µg/ml, 10 µg/ml and 100 µg/ml) plus Con A (2 µg/ml) and ZR (6.6 µg/ml and 66 µg/ml), GR (3.3 µg/ml and 33 µg/ml) respectively for 48 hrs. The production of IFN-γ and IL-4 were determined by ELISA.
Results : No toxicity was found in splenocytes treated with SG extract for 48 hrs at the concentration of 0 µg/ml, 1 µg/ml, 10 µg/ml and 100 µg/ml, respectively. The production of IFN-γ increased to 23,968.7 pg/ml (p<0.001) while that of IL-4 significantly decreased to 14.1 pg/m l(p<0.05) only at the SG concentration of 100 µg/ml. With the GR concentration of 33 μg/ml in SG extract, the production of IFN-γ rose to 32,102.2 pg/ml (p<0.001) while that of IL-4 (p<0.05) declined to 34.2 pg/ml. However, there was no significant observation with regard to the effect of ZR on production of IFN-γ and IL-4.
Conclusions : This study suggests an antiallergic effect of Senggang Gamcho-tang, which leads to the implication that SG extract may be used to enhance human immune function.
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참고문헌 (33)
참고문헌 신청
[학술지(정기간행물)] -
Cinatl J / 2003 / Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus / Lancet 361 (9347) : 2045 ~ 2046
Erb KJ / 1996 / The role of Th2 type CD4+ T cells and Th2 type CD8+T cell in asthma / Immunol Cell Biol 74 (2) : 206 ~ 208
Holgate ST / 1998 / Asthma and allergy-disorders of civilization / QJM 91 (3) : 171 ~ 184
Isao K / 1993 / Chemical constituents of licorice roots / 현대동양의학 14 : 80 ~ 89
Cinatl J / 2003 / Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus / Lancet 361 (9347) : 2045 ~ 2046
Erb KJ / 1996 / The role of Th2 type CD4+ T cells and Th2 type CD8+T cell in asthma / Immunol Cell Biol 74 (2) : 206 ~ 208
Holgate ST / 1998 / Asthma and allergy-disorders of civilization / QJM 91 (3) : 171 ~ 184
Isao K / 1993 / Chemical constituents of licorice roots / 현대동양의학 14 : 80 ~ 89
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