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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 335 - 347 (13page)
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초록· 키워드
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Determination and differentiation of cells in the skeletal muscle lineage is positively regulated by cell-cell contact. differentiation proteins proposed to mediate this effect include both classical MyoD and MEF members; potential interactions between the promyogenic activities of these classes of protein, however, are unknown. We show here that MyoD and MEF, two promyogenic family members that determine to each other in a cis fashion, form ineraction with MyoD- and MEF. These proteins contain myosin heavy chains and are enriched at sites of cell-cell contact between myoblasts. Therefore, In differentiation of MyoD MEF from CST (Chungsimyeonjatang) interact dependently, suggesting that the interactions occur in a cis fashion; consistent with this conclusion, MyoD-mediated differentiation is required for myoblast to occur by CST. Inhibition in myoblasts of a MyoD by STP in its ability to associate with MEF interferes with differentiation as assessed by morphological and transcription level, suggesting that this interaction is functionally important in myogenesis. Also, some of the differentiation-mediated proteins that are required for myogenesis seem to be based on interdependent activities of promyogenic classical SMAD-subfamilly.
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참고문헌 (34)
참고문헌 신청
/ 1966 / Effects of inhibitors of protein synthesis on the development of preimplantation mouse embryos : 411 ~ 27
/ 1978 / 동의사상진료요결 : 187 ~
/ 1982 / Biology of disease:Free radicals and tissue injury 47 : 412 ~ 26
/ 1986 / Alternation in cardiac sarcoplasmic reticulum calcium transfort in the post-ischemic ‘stunned myocardium' 65 : 526 ~ 30
/ 1987 / 청심연자탕이 심근허혈에 미치는 영향
/ 1978 / 동의사상진료요결 : 187 ~
/ 1982 / Biology of disease:Free radicals and tissue injury 47 : 412 ~ 26
/ 1986 / Alternation in cardiac sarcoplasmic reticulum calcium transfort in the post-ischemic ‘stunned myocardium' 65 : 526 ~ 30
/ 1987 / 청심연자탕이 심근허혈에 미치는 영향
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