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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 398 - 408 (11page)
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Objective : Graves' disease encompasses hyperthyroidism and diffused goiter associated with auto-antibodies to the thyroid stimulating hormone (TSH) receptors. In clinical environment, treatments of Graves' disease have many side effects such as recurrence and hypothyroidism. We've studied the effects of Sipyukmiyukieum on DNA synthesis, cAMP synthesis, and MHC-class II expression of FRTL-5 thyroid cells were studied.
Methods : DNA synthesis was investigated by using BrdU staining and cAMP synthesis by ELISA kit, and expression of interferon-γ activated MHC class Ⅱ by Flow cytometer.
Results : After introduction of Sipyukmiyukieum, significant inhibition of DNA synthesis, cAMP synthesis, and expression of interferon-γ activated MHC class Ⅱ of FRTL-5 thyroid cells was observed.
Conclusions : Judging from these results, Sipyukmiyukieum has potential as a potent herbal treatment for inhibiting the enlargement of goiter, synthesis of abnormal thyroidal hormones, and autoimmuine responses of Graves' disease.
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참고문헌 (31)
참고문헌 신청
/ 1978 / Antithyroid drugs 3 : 305 ~ 348
/ 1983 / Aberrant expression of HLA-DR antigen on thyrocytes in Graves' disease:relevance for autoimmunity 2 (8359) : 1111 ~ 5
/ 1983 / Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity 2 (8359) : 1115 ~ 9
/ 1985192-6 / Transcriptional control of thyroglobulin gene expression by cyclic AMP
/ 1986 / 逍遙散加味方이 Sodium Levothyroxine 투여로 유발된 흰쥐의 갑상선기능항진증에 미치는 影響
/ 1983 / Aberrant expression of HLA-DR antigen on thyrocytes in Graves' disease:relevance for autoimmunity 2 (8359) : 1111 ~ 5
/ 1983 / Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity 2 (8359) : 1115 ~ 9
/ 1985192-6 / Transcriptional control of thyroglobulin gene expression by cyclic AMP
/ 1986 / 逍遙散加味方이 Sodium Levothyroxine 투여로 유발된 흰쥐의 갑상선기능항진증에 미치는 影響
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