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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 149 - 165 (17page)
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ABSTRACT
The Effects of Saengkankunbi-tang on Proliferation, Apoptosis and Cell Signaling Pathways of HepG2 Cells
Kim Jae-Yong, Young-Chul Kim, Jang-Hoon Lee, Hong-Jung Woo
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University
Objectives : This study was done to evaluate the effects of Saengkankunbi-tang on cell-viability, proliferation, cell-cycle, apoptosis and DNA replication on HepG2 cell and to find out by which molecular-biological mechamism by which Saengkankunbi-tang operates.
Methods : The MTT assay, cell counting assay, [3H]-thymidine incorporation assay, flow cytometric analysis, tryphan blue exclusion assay, western blot analysis, quantative RT-PCR were taken.
Results : Saengkankunbi-tang had no effect on proliferation, cell-cycle and DNA replications of HepG2 cells, while it improved cell viability and reduced apoptosis, and it activated Akt and NFκB. But, it did not produce an effect on cell viability and apoptosis when PI3K/Akt pathway was blocked by LY294002 nor when NFκB activation was blocked by DN-IκB.
Conclusion : These results suggests that Saengkankunbi-tang improves cell viability and reduces apoptosis of HepG2 cells, by activating NFκB through PI3K/Akt pathway.
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참고문헌 (35)
참고문헌 신청
/ 1978 / 간염유관항원양성 만성 간질환 2례 10 : 43 ~ 44
/ 1981 / 生肝健脾湯이 간장의 대사와 재생능력에 미치는 영향
/ 1982 / 만성간염 3136례에 대한 임상분석과 生肝健脾湯의 치료효과 : 218 ~ 225
/ 1995 / Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappaB 376 : 167 ~ 170
/ 1996 / An essential role for NF kappaB in preventing TNF alpha induced cell death 274 : 782 ~ 784
/ 1981 / 生肝健脾湯이 간장의 대사와 재생능력에 미치는 영향
/ 1982 / 만성간염 3136례에 대한 임상분석과 生肝健脾湯의 치료효과 : 218 ~ 225
/ 1995 / Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappaB 376 : 167 ~ 170
/ 1996 / An essential role for NF kappaB in preventing TNF alpha induced cell death 274 : 782 ~ 784
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