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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 100 - 111 (12page)
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Objectives : This study investigated the impact of Caesalpinia sappan L. on oxidative damage and inflammatory relevant factor in RAW 264.7 cells and human umbilical vein endothelial cells (HUVEC).
Methods : We determined whether fractionated EtOH extracts of Caesalpinia sappan L. (CSL) inhibit free radical generation such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), reactive oxygen species (ROS) and nitric oxide (NO) and pro-inflammatory cytokines in lipopolysaccharide (LPS)-treated RAW 264.7 cells and HUVEC.
Result :1. DPPH removal capacity was increased by CSL.
2. LPS-induced ROS, and NO inhibitory capacity were increased by CSL.
3. LPS-induced cell death of Raw 264.7 cells was decreased by CSL.
4. The amount of cytokine generation in Raw 264.7 cell was decreased significantly by CSL.
5. The amount of cytokine generation in HUVEC was decreased significantly by CSL.
Conclusions : These results suggest that CSL supplement may attenuate oxidative stress by elevated antioxidative processes, and suppress inflammatory mediator activation.
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참고문헌 (36)
참고문헌 신청
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Blois MS / 1958 / Antioxidant determination by the use of stable free radical / Nature 181 : 1199 ~ 1200
De Nardin E / 2001 / The role of inflammatory and immunological mediators in periodontitis and cardiovascular disease / Ann Periodontol 6 (1) : 30 ~ 40
Il Yun Jeong / 2008 / Anti-inflammatory Activity of an Ethanol Extract of Caesalpinia sappan L. in LPS-induced RAW 264.7 Cells / Preventive Nutrition and Food Science 13 (4)
Kujala TS / 2000 / Phenolics and betacyanins in red beetroot (Beta vulgaris) root: distribution and effect of cold storage on the content of total phenolics and three indivi
Blois MS / 1958 / Antioxidant determination by the use of stable free radical / Nature 181 : 1199 ~ 1200
De Nardin E / 2001 / The role of inflammatory and immunological mediators in periodontitis and cardiovascular disease / Ann Periodontol 6 (1) : 30 ~ 40
Il Yun Jeong / 2008 / Anti-inflammatory Activity of an Ethanol Extract of Caesalpinia sappan L. in LPS-induced RAW 264.7 Cells / Preventive Nutrition and Food Science 13 (4)
Kujala TS / 2000 / Phenolics and betacyanins in red beetroot (Beta vulgaris) root: distribution and effect of cold storage on the content of total phenolics and three indivi
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